1928. Considered as therapeutic “magic-bullets”, antibiotics have revolutionized modern
medicine and made many complicated medical procedures possible. The 1960s and 1970s …

We are in a crisis of bacterial resistance. For economic reasons, most pharmaceutical
companies are abandoning antimicrobial discovery efforts, while, in health care itself …

In the event of another bioterrorism attack with a bacterial agent, antibiotics will be critical
medical countermeasures to have in the US Strategic National Stockpile. Conventional …

Highlights•Medicinal chemistry generates improved antibiotics from core scaffolds that can
evade resistance.•Antibiotic chemical space is different than that of other drugs.•Antibiotic …

Gram-negative bacterial infections are associated with high morbidity and mortality, due to
limited therapeutic options. Multidrug resistance is a key factor. A survey of the epidemiology …

Drug repurposing, or identifying new uses for existing drugs, has emerged as an alternative
to traditional drug discovery processes involving de novo synthesis. Drugs that are currently …

Antimicrobial resistance to drugs is a serious threat to public health. Different strategies have
been adopted to deal with antimicrobial resistance to known drugs, one such strategy is the …

Anitibiotic resistance is developing at an alarming rate and is one of the world's most
pressing health problems. New methods for developing microbe-selective antibacterial …

Bacteria show resistance to antibiotic drugs through a variety of mechanisms. Moreover, the
development of even new mechanisms of resistance have resulted in the simultaneous …

Antibiotics are essential weapons in our fight against infectious disease, yet the
consequences of broad-spectrum antibiotic use on microbiome stability and pathogen …