Bacteria: drug resistance spreads, but few new drugs emerge

C Shekhar - Chemistry & biology, 2010 - cell.com
That fighting bacteria is tough should come as no surprise. After all, bacteria outnumber
humans by an estimated billion trillion to one and reproduce halfa-million times faster than …

Suppression of emergence of resistance in pathogenic bacteria: keeping our powder dry, part 2

GL Drusano, W Hope, A MacGowan… - Antimicrobial agents and …, 2016 - Am Soc Microbiol
We are in a crisis of bacterial resistance. For economic reasons, most pharmaceutical
companies are abandoning antimicrobial discovery efforts, while, in health care itself …

Plant-derived antimicrobials: Insights into mitigation of antimicrobial resistance

SK Yang, LY Low, PSX Yap, K Yusoff… - Records of Natural …, 2018 - research.monash.edu
Antibiotic resistance had first been reported not long after the discovery of the first antibiotic
and has remained a major public health issue ever since. Challenges are constantly …

Resistance-resistant antibiotics

E Oldfield, X Feng - Trends in Pharmacological Sciences, 2014 - cell.com
New antibiotics are needed because drug resistance is increasing while the introduction of
new antibiotics is decreasing. We discuss here six possible approaches to develop …

Beyond the discovery void: New targets for antibacterial compounds

CE Broughton, HA Van Den Berg… - Science …, 2016 - journals.sagepub.com
Antibiotics save many lives, but their efficacy is under threat: overprescription, population
growth, and global travel all contribute to the rapid origination and spread of resistant …

[图书][B] Drug discovery targeting drug-resistant bacteria

P Kesharwani, S Chopra, A Dasgupta - 2020 - books.google.com
Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of
developments in fighting drug-resistant bacteria. The book covers the majority of microbial …

Alternative therapies to antibiotics to combat drug-resistant bacterial pathogens

G Kaul, M Shukla, A Dasgupta, S Chopra - Antibacterial Drug Discovery to …, 2019 - Springer
The unabated emergence and spread of antimicrobial resistance (AMR) within both
nosocomial and community environments is the driving force behind the urgent need to …

Recent development of antibacterial agents to combat drug-resistant Gram-positive bacteria

MM Konai, S Barman, Y Acharya, K De… - Drug Discovery Targeting …, 2020 - Elsevier
Bacteria are increasingly developing resistance against the antibiotics of last resort, which
has created enormous threats in the face of global public health. In order to address this …

[引用][C] New drugs and emerging leads in antibacterial drug discovery

DG Brown - 2017 - Elsevier

Novel approaches to the treatment of multidrug-resistant bacteria, Volume II

P Pusparajah, V Letchumanan, BH Goh… - Frontiers in …, 2022 - frontiersin.org
Overall, the articles in this Research Topic highlight a spectrum of research encompassing
the importance of pursuing work to explore new ways of treating multidrug resistant bacteria …