Antigen cross-presentation in young tumor-bearing hosts promotes CD8+ T cell terminal differentiation
The immune system undergoes a progressive functional remodeling with age.
Understanding how age bias shapes antitumor immunity is essential in designing effective …
Understanding how age bias shapes antitumor immunity is essential in designing effective …
The aged tumor microenvironment limits T cell control of cancer
The etiology and effect of age-related immune dysfunction in cancer is not completely
understood. Here we show that limited priming of CD8+ T cells in the aged tumor …
understood. Here we show that limited priming of CD8+ T cells in the aged tumor …
Clonal spreading of tumor-infiltrating T cells underlies the robust antitumor immune responses
H Aoki, M Tsunoda, H Ogiwara, H Shimizu, H Abe… - Cancer Immunology …, 2023 - AACR
The repertoire of tumor-infiltrating T cells is an emerging method for characterizing effective
antitumor T-cell responses. Oligoclonal expansion of the tumor T-cell repertoire has been …
antitumor T-cell responses. Oligoclonal expansion of the tumor T-cell repertoire has been …
No intrinsic deficiencies in CD8+ T cell-mediated antitumor immunity with aging
LA Norian, PM Allen - The Journal of Immunology, 2004 - journals.aai.org
Aging is associated with a decline in immune function, particularly within the T cell
compartment. Because CD8+ T cells are critical mediators of protective immunity against …
compartment. Because CD8+ T cells are critical mediators of protective immunity against …
Age-induced changes in anti-tumor immunity alter the tumor immune infiltrate and impact response to immuno-oncology treatments
SI Sitnikova, JA Walker, LB Prickett, M Morrow… - Frontiers in …, 2023 - frontiersin.org
Introduction Immuno-oncology (IO) research relies heavily on murine syngeneic tumor
models. However, whilst the average age for a cancer diagnosis is 60 years or older, for …
models. However, whilst the average age for a cancer diagnosis is 60 years or older, for …
Organized immune cell interactions within tumors sustain a productive T-cell response
MA Cardenas, N Prokhnevska… - International …, 2021 - academic.oup.com
Tumor-infiltrating CD8 T cells are associated with improved patient survival and response to
immunotherapy in various cancers. Persistent antigen leads to CD8 T-cell exhaustion …
immunotherapy in various cancers. Persistent antigen leads to CD8 T-cell exhaustion …
[HTML][HTML] Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice
Background Aging has long been thought to be a major risk factor for various types of
cancers. However, accumulating evidence indicates increased resistance of old animals to …
cancers. However, accumulating evidence indicates increased resistance of old animals to …
Isolation of immune cells from primary tumors
SK Watkins, Z Zhu, KE Watkins, AA Hurwitz - JoVE (Journal of Visualized …, 2012 - jove.com
Tumors create a unique immunosuppressive microenvironment (tumor microenvironment,
TME) whereby leukocytes are recruited into the tumor by various chemokines and growth …
TME) whereby leukocytes are recruited into the tumor by various chemokines and growth …
Cotransfer of antigen and contextual information harmonizes peripheral and lymph node conventional dendritic cell activation
T cell responses against infections and cancer are directed by conventional dendritic cells
(cDCs) in lymph nodes distant from the site of challenge. Migratory cDCs, which travel from …
(cDCs) in lymph nodes distant from the site of challenge. Migratory cDCs, which travel from …
Nurture over nature for old antitumor T cells
JE Wilson, JŽ Nikolich - Nature Immunology, 2024 - nature.com
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