Impairment of episodic memory, a class of memory for spatiotemporal context of an event, is
an early symptom of Alzheimer's disease. Both spatial and temporal information are …

Alzheimer's disease (AD) is characterized by a progressive dysfunction of central neurons.
Recent experimental evidence indicates that in the cortex, in addition to the silencing of a …

Alzheimer's disease (AD) is an irreversible and highly progressive neurodegenerative
disease. Clinically, patients with AD display impairments in episodic and spatial memory …

The present review summarizes converging evidence from animal and human studies that
an early target of amyloid pathology is synaptic activity in the DG (dentate gyrus)/CA3 …

Abstract β-amyloid is hypothesized to harm neural function and cognitive abilities by
perturbing synaptic transmission and plasticity in Alzheimer's disease (AD). To assess the …

In Alzheimer's disease, amyloid beta peptide (Aβ) accumulation is associated with
hippocampal network dysfunction. Intrahippocampal injections of Aβ induce aberrant …

In Alzheimer's disease, the cholinergic damage (reduced neurotransmission) and cognitive
impairment occur long before β-amyloid (Aβ) plaque formation. It has not been established …

The capacity to remember temporal relationships between different events is essential to
episodic memory, but little is currently known about its underlying mechanisms. We …

Amyloid-β protein (Aβ) is thought to play a central pathogenic role in Alzheimer's disease.
Aβ can impair synaptic transmission, but little is known about the effects of Aβ on intrinsic …

Patients with Alzheimer's disease (AD) suffer from spatial memory impairment and
wandering behavior, but the brain circuit mechanisms causing such symptoms remain …