SALL1 is a mammalian homolog of the Drosophila region-specific homeotic gene spalt (sal);
heterozygous mutations in SALL1 in humans lead to Townes-Brocks syndrome. We have …

Mutations in SALL4, the human homolog of the Drosophila homeotic gene spalt (sal), cause
the autosomal dominant disorder known as Okihiro syndrome. In this study, we show that a …

Sall1 is a multi-zinc finger transcription factor that regulates kidney organogenesis. It is
considered to be a transcriptional repressor, preferentially localized on heterochromatin …

spalt (sal) of Drosophila melanogaster is an important developmental regulator gene and
encodes a zinc finger protein of unusual but characteristic structure. Two human sal-like …

The genes of the spalt (sal) family play fundamental roles during animal development. The
two members of this family in Drosophila, spalt (sal) and spalt-related (salr) encode Zn-finger …

Congenital anomalies of the kidney and urinary tract (CAKUT) account for 40–50% of
chronic kidney disease that manifests in the first two decades of life. Thus far, 31 monogenic …

Abstract SALL4 (sal-like protein 4) is a pluripotency transcription factor, which is highly
expressed in embryonic stem (ES) cells and which is essential for mouse preimplantation …

The spermatogenic lineage is established after birth when gonocytes migrate to the
basement membrane of seminiferous tubules and give rise to spermatogonial stem cells …

The balanced self-renewal and differentiation of nephron progenitors are critical for kidney
development and controlled, in part, by the transcription factor Six2, which antagonizes …

The slit (sli) gene, encoding a secreted glycoprotein, has been demonstrated to play a vital
role in axonal guidance in Drosophila melanogaster by acting as a signalling ligand for the …