PI3K/AKT signaling pathway: a possible target for adjuvant therapy in COVID-19

MR Khezri - Human Cell, 2021 - Springer
To the editor Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2), poses a major challenge to the world's healthcare …

The PI3K/Akt/mTOR pathway: a potential pharmacological target in COVID-19

MS Basile, E Cavalli, J McCubrey… - Drug discovery today, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) has emerged as a serious threat to global
health. The disregulation of the phosphatidylinositol 3-kinase/protein kinase B/mammalian …

PI3Kδ inhibition as a potential therapeutic target in COVID-19

G Palma, T Pasqua, G Silvestri, C Rocca… - Frontiers in …, 2020 - frontiersin.org
The spread of the novel human respiratory coronavirus (SARS-CoV-2) is a global public
health emergency. There is no known successful treatment as of this time, and there is a …

Targeting the PI3K/Akt/mTOR pathway: A therapeutic strategy in COVID-19 patients

R Abu-Eid, FJ Ward - Immunology letters, 2021 - Elsevier
Some COVID-19 patients suffer complications from anti-viral immune responses which can
lead to both a dangerous cytokine storm and development of blood-borne factors that render …

[HTML][HTML] Capivasertib restricts SARS-CoV-2 cellular entry: a potential clinical application for COVID-19

F Sun, C Mu, HF Kwok, J Xu, Y Wu, W Liu… - … Journal of Biological …, 2021 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has led to more than 150 million infections …

PI3K/Akt/mTOR pathway: a potential target for anti-SARS-CoV-2 therapy

S Fattahi, Z Khalifehzadeh-Esfahani… - Immunologic …, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is a viral infection caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). A single-stranded RNA virus from a β …

NF-κB pathway as a potential target for treatment of critical stage COVID-19 patients

R Kircheis, E Haasbach, D Lueftenegger… - Frontiers in …, 2020 - frontiersin.org
Patients infected with SARS-CoV-2 show a wide spectrum of clinical manifestations ranging
from mild febrile illness and cough up to acute respiratory distress syndrome, multiple organ …

Molecular pathways triggered by COVID-19 in different organs: ACE2 receptor-expressing cells under attack? A review

L Saba, C Gerosa, D Fanni, F Marongiu… - European Review for …, 2020 - iris.unica.it
OBJECTIVE: In human pathology, SARS-CoV-2 utilizes multiple molecular pathways to
determine structural and biochemical changes within the different organs and cell types. The …

[HTML][HTML] From cell to symptoms: The role of SARS-CoV-2 cytopathic effects in the pathogenesis of COVID-19 and long COVID

P Gonzalez-Garcia, O Fiorillo Moreno… - International Journal of …, 2023 - mdpi.com
Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection triggers various
events from molecular to tissue level, which in turn is given by the intrinsic characteristics of …

The potential involvement of JAK-STAT signaling pathway in the COVID-19 infection assisted by ACE2

J Luo, S Lu, M Yu, L Zhu, C Zhu, C Li, J Fang, X Zhu… - Gene, 2021 - Elsevier
COVID-19, a novel identified coronavirus disease due to Severe Acute Respiratory
Syndrome coronaviruses 2 (SARS-Cov-2) infection, has posed a significant threat to public …