Tip off the HAT– Epigenetic control of learning and memory by Drosophila Tip60
Disruption of epigenetic gene control mechanisms involving histone acetylation in the brain
causes cognitive impairment, a debilitating hallmark of most neurodegenerative disorders …
causes cognitive impairment, a debilitating hallmark of most neurodegenerative disorders …
Epigenetic Control of Learning and Memory in Drosophila by Tip60 HAT Action
Disruption of epigenetic gene control mechanisms in the brain causes significant cognitive
impairment that is a debilitating hallmark of most neurodegenerative disorders, including …
impairment that is a debilitating hallmark of most neurodegenerative disorders, including …
Disruption of Tip60 HAT mediated neural histone acetylation homeostasis is an early common event in neurodegenerative diseases
Epigenetic dysregulation is a common mechanism shared by molecularly and clinically
heterogenous neurodegenerative diseases (NDs). Histone acetylation homeostasis …
heterogenous neurodegenerative diseases (NDs). Histone acetylation homeostasis …
dTip60 HAT Activity Controls Synaptic Bouton Expansion at the Drosophila Neuromuscular Junction
Background Histone acetylation of chromatin plays a key role in promoting the dynamic
transcriptional responses in neurons that influence the neuroplasticity linked to cognitive …
transcriptional responses in neurons that influence the neuroplasticity linked to cognitive …
Microarray analysis uncovers a role for Tip60 in nervous system function and general metabolism
Background Tip60 is a key histone acetyltransferase (HAT) enzyme that plays a central role
in diverse biological processes critical for general cell function; however, the chromatin …
in diverse biological processes critical for general cell function; however, the chromatin …
Tip60 HAT Activity Mediates APP Induced Lethality and Apoptotic Cell Death in the CNS of a Drosophila Alzheimer's Disease Model
SK Pirooznia, J Sarthi, AA Johnson, MS Toth, K Chiu… - 2012 - journals.plos.org
Histone acetylation of chromatin promotes dynamic transcriptional responses in neurons
that influence neuroplasticity critical for cognitive ability. It has been demonstrated that Tip60 …
that influence neuroplasticity critical for cognitive ability. It has been demonstrated that Tip60 …
Restoring Tip60 HAT/HDAC2 balance in the neurodegenerative brain relieves epigenetic transcriptional repression and reinstates cognition
Cognitive decline is a debilitating hallmark during preclinical stages of Alzheimer's disease
(AD), yet the causes remain unclear. Because histone acetylation homeostasis is critical for …
(AD), yet the causes remain unclear. Because histone acetylation homeostasis is critical for …
Increasing Tip60 HAT levels rescues axonal transport defects and associated behavioral phenotypes in a Drosophila Alzheimer's disease model
AA Johnson, J Sarthi, SK Pirooznia… - Journal of …, 2013 - Soc Neuroscience
Axonal transport defects and axonopathy are prominent in early preclinical stages of
Alzheimer's disease (AD), often preceding known disease-related pathology by over a year …
Alzheimer's disease (AD), often preceding known disease-related pathology by over a year …
Epigenetic Regulation of Axonal Growth of Drosophila Pacemaker Cells by Histone Acetyltransferase Tip60 Controls Sleep
SK Pirooznia, K Chiu, MT Chan, JE Zimmerman… - Genetics, 2012 - academic.oup.com
Tip60 is a histone acetyltransferase (HAT) enzyme that epigenetically regulates genes
enriched for neuronal functions through interaction with the amyloid precursor protein (APP) …
enriched for neuronal functions through interaction with the amyloid precursor protein (APP) …
Tip60 protects against amyloid-β-induced transcriptomic alterations via different modes of action in early versus late stages of neurodegeneration
Alzheimer's disease (AD) is an age-related neurodegenerative disorder hallmarked by
amyloid-β (Aβ) plaque accumulation, neuronal cell death, and cognitive deficits that worsen …
amyloid-β (Aβ) plaque accumulation, neuronal cell death, and cognitive deficits that worsen …