Entorhinal grid cells and hippocampal place cells are key systems for mammalian
navigation. By combining information from different sensory modalities, they provide abstract …

The discovery of neuronal systems dedicated to computing spatial information, composed of
functionally distinct cell types such as place and grid cells, combined with an extensive body …

A progressive loss of navigational abilities in old age has been observed in numerous
studies, but we have only limited understanding of the neural mechanisms underlying this …

Age-related declines in spatial navigation are well-known in human and non-human
species. Studies in non-human species suggest that alteration in hippocampal and other …

Age-related spatial navigation decline is more pronounced in patients with mild cognitive
impairment (MCI) and Alzheimer's disease (AD) dementia. We used a realistic-looking …

Spatial navigation is a complex cognitive skill that is necessary for everyday functioning in
the environment. However, navigational skills are not typically measured in most test …

Older adults have difficulties in navigating unfamiliar environments and updating their
wayfinding behavior when faced with blocked routes. This decline in navigational …

Navigation abilities show marked decline in both normal ageing and dementia. Path
integration may be particularly affected, as it is supported by the hippocampus and …

Efficient spatial navigation requires not only accurate spatial knowledge but also the
selection of appropriate strategies. Using a novel paradigm that allowed us to distinguish …

Navigation abilities decline with age, partly due to deficits in numerous component
processes. Impaired switching between these various processes (ie, switching navigational …