Despite a decrease in the prevalence of colorectal cancer (CRC) over the last 40 y, the
prevalence of CRC in people under 50 y old is increasing around the globe. Early onset (≤ …

Simple Summary The incidence of non-hereditary cancer in the left colon and rectum is
increasing in young patients worldwide for unknown reasons. To understand this …

The immune microenvironment has profound impacts on the initiation and progression of
colorectal cancer (CRC). Therefore, the goal of this article is to identify two robust immune …

The tumor microenvironment is a complex ecosystem formed by distinct and interacting cell
populations, and its composition is related to cancer prognosis and response to clinical …

Increasing studies have highlighted the effects of the tumor immune micro-environment
(TIM) on colon cancer (CC) tumorigenesis, prognosis, and metastasis. However, there is no …

Background Cancer immunity is based on the interaction of a multitude of cells in the spatial
context of the tumour tissue. Clinically relevant immune signatures are therefore anticipated …

To define differences in tumor microenvironment (TME) immune phenotypes between right
and left colorectal cancers (CRCs) and explore their therapeutic implications. Gene …

Background The incidence and mortality rates of colon adenocarcinoma (COAD), which is
the fourth most diagnosed cancer worldwide, are high. A subset of patients with COAD has …

Antitumoral immunity requires organized, spatially nuanced interactions between
components of the immune tumor microenvironment (iTME). Understanding this coordinated …

The prognostic value of immune cell infiltration within the tumor microenvironment (TME)
has been extensively investigated via histological and genomic approaches. Based on the …