[HTML][HTML] Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19

PA Szabo, P Dogra, JI Gray, SB Wells, TJ Connors… - Immunity, 2021 - cell.com
Immune response dynamics in coronavirus disease 2019 (COVID-19) and their severe
manifestations have largely been studied in circulation. Here, we examined the relationship …

[HTML][HTML] Cytokine storm signature in patients with moderate and severe COVID-19

O Kalinina, A Golovkin, E Zaikova, A Aquino… - International Journal of …, 2022 - mdpi.com
Hypercytokinemia, found in SARS-CoV-2 infection, contributes to multiple organ
dysfunctions with acute respiratory distress syndrome, shock etc. The aim of this study was …

Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and related conditions

R Noroozi, W Branicki, K Pyrc, PP Łabaj, E Pospiech… - Cytokine, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic in early 2020. The infection has been associated with a wide range of clinical …

[HTML][HTML] Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients

ZS Xu, T Shu, L Kang, D Wu, X Zhou, BW Liao… - Signal transduction and …, 2020 - nature.com
In December 2019, a novel coronavirus that is related to severe acute respiratory syndrome
coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) in …

[HTML][HTML] SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

CJ Neufeldt, B Cerikan, M Cortese, J Frankish… - Communications …, 2022 - nature.com
SARS-CoV-2 is a novel virus that has rapidly spread, causing a global pandemic. In the
majority of infected patients, SARS-CoV-2 leads to mild disease; however, in a significant …

[HTML][HTML] mRNA-lncRNA Co-expression network analysis reveals the role of lncRNAs in immune dysfunction during severe SARS-CoV-2 infection

S Mukherjee, B Banerjee, D Karasik… - Viruses, 2021 - mdpi.com
The recently emerged SARS-CoV-2 virus is responsible for the ongoing COVID-19
pandemic that has rapidly developed into a global public health threat. Patients severely …

COVID-19 hyperinflammation: what about neutrophils?

A Didangelos - MSphere, 2020 - Am Soc Microbiol
ABSTRACT COVID-19 is often related to hyperinflammation that drives lung or multiorgan
injury. The immunopathological mechanisms that cause excessive inflammation are under …

[HTML][HTML] COVID-19 signalome: Pathways for SARS-CoV-2 infection and impact on COVID-19 associated comorbidity

K Lundstrom, A Hromić-Jahjefendić, E Bilajac… - Cellular …, 2023 - Elsevier
The COVID-19 pandemic has been the focus of research the past two years. The major
breakthrough was made by discovering pathways related to SARS-CoV-2 infection through …

Lung expression of human angiotensin-converting enzyme 2 sensitizes the mouse to SARS-CoV-2 infection

K Han, RV Blair, N Iwanaga, F Liu… - American journal of …, 2021 - atsjournals.org
Preclinical mouse models that recapitulate some characteristics of coronavirus disease
(COVID-19) will facilitate focused study of pathogenesis and virus–host responses. Human …

[HTML][HTML] Heightened circulating interferon-inducible chemokines, and activated pro-cytolytic Th1-cell phenotype features covid-19 aggravation in the second week of …

C Tincati, ES Cannizzo, M Giacomelli… - Frontiers in …, 2020 - frontiersin.org
Covid-19 features a delayed onset of critical illness occurring approximately one week from
the beginning of symptoms, which corresponds to the bridging of innate and adaptive …