Alcohol teratogenesis: mechanisms of damage and strategies for intervention

CR Goodlett, KH Horn, FC Zhou - Experimental biology and …, 2005 - journals.sagepub.com
There are multiple mechanisms by which alcohol can damage the developing brain, but the
type of damage induced will depend on the amount and developmental timing of exposure …

[HTML][HTML] Mechanisms of alcohol-induced damage to the developing nervous system

CR Goodlett, KH Horn - Alcohol Research & Health, 2001 - ncbi.nlm.nih.gov
Numerous mechanisms likely contribute to the damaging effects of prenatal alcohol
exposure on the developing fetus and particularly the developing central nervous system …

Amelioration of fetal alcohol-related neurodevelopmental disorders in rats: exploring pharmacological and environmental treatments

JH Hannigan, RF Berman - Neurotoxicology and teratology, 2000 - Elsevier
Fetal alcohol syndrome (FAS) and alcohol-related neurodevelopmental disorders (ARNDs)
in children are characterized by life-long compromises in learning, memory, and adaptive …

Fetal alcohol exposure and temporal vulnerability: regional differences in cell loss as a function of the timing of binge‐like alcohol exposure during brain development

SE Maier, JA Miller, JM Blackwell… - Alcoholism: Clinical and …, 1999 - Wiley Online Library
This study was conducted to determine the temporal and regional vulnerability of the brain
as a function of exposure to alcohol during brain development. Our goal was to manipulate …

Moderate fetal alcohol exposure impairs the neurogenic response to an enriched environment in adult mice

IY Choi, AM Allan… - Alcoholism: Clinical and …, 2005 - Wiley Online Library
Background: Prenatal ethanol exposure results in a spectrum of cognitive and behavioral
deficits and affects an estimated thirteen percent of children born in the United States. The …

[HTML][HTML] Alcohol and the developing brain: neuroanatomical studies

WJA Chen, SE Maier, SE Parnell… - Alcohol Research & …, 2003 - ncbi.nlm.nih.gov
One of the distinguishing features of prenatal alcohol exposure is impaired cognitive and
behavioral function resulting from damage to the central nervous system. Information …

Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure

ML Kleiber, K Mantha, RL Stringer… - Journal of …, 2013 - Springer
Background Maternal alcohol consumption is known to adversely affect fetal
neurodevelopment. While it is known that alcohol dose and timing play a role in the …

What research with animals is telling us about alcohol-related neurodevelopmental disorder

JH Hannigan - Pharmacology Biochemistry and Behavior, 1996 - Elsevier
The substantial advances in understanding fetal alcohol syndrome over the past 20 years
were made in large part because of research with animals. This review illustrates recent …

Teratogenic effects of alcohol on brain development

JR West, CR Goodlett - Annals of medicine, 1990 - Taylor & Francis
There is convincing evidence that alcohol is teratogenic both in humans and animals and
that its most devastating effects are on the developing brain. However, much information is …

Fetal alcohol syndrome: the vulnerability of the developing brain and possible mechanisms of damage

JR West, WJA Chen, NJ Pantazis - Metabolic brain disease, 1994 - Springer
Fetal alcohol exposure has multiple deleterious effects on brain development, and
represents a leading known cause of mental retardation. This review of the effects of alcohol …