Transcriptional networks regulate cell fate decisions, which occur at the level of individual
cells. However, much of what we know about their structure and function comes from studies …

Understanding how a single cell, the zygote, can divide and differentiate to produce the
diverse animal cell types is a central goal of developmental biology research. The model …

Combining clonal analysis with a computational agent based model, we investigate how
tissue-specific stem cells for neural retina (NR) and retinal pigmented epithelium (RPE) of …

Tracing developmental lineages | Nature Methods Skip to main content Thank you for visiting
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Lineage tracing is a method that delineates all progeny produced by a single cell or a group
of cells. The possibility of performing lineage tracing initiated the field of Developmental …

The quest for the origin of diversity in biology is as old as the discipline itself. Much as
evolutionary biologists sought to fathom the diversification of life forms into discrete, self …

Using a compendium of cell-state-specific gene expression data, we identified genes that
uniquely define cell states, including those thought to represent various developmental …

Mechanisms of development rank among the great conundrums of biology: how are the
diverse cell types that comprise an adult organism generated from a single genome? While …

High-throughput mapping of cellular differentiation hierarchies from single-cell data
promises to empower systematic interrogations of vertebrate development and disease …

Cell identity is governed by the complex regulation of gene expression, represented as gene-
regulatory networks. Here we use gene-regulatory networks inferred from single-cell multi …