Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes
Our understanding of the genetics of the human cerebral cortex is limited both in terms of the
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …
The genetic architecture of the human cerebral cortex
KL Grasby, N Jahanshad, JN Painter, L Colodro-Conde… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological …
Variations in human cortical surface area and thickness are associated with neurological …
Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive …
Volumetric variations of the human brain are heritable and are associated with many brain-
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
[HTML][HTML] Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology
Brain morphology has been shown to be highly heritable, yet only a small portion of the
heritability is explained by the genetic variants discovered so far. Here we extended the …
heritability is explained by the genetic variants discovered so far. Here we extended the …
The dynamic role of genetics on cortical patterning during childhood and adolescence
JE Schmitt, MC Neale, B Fassassi… - Proceedings of the …, 2014 - National Acad Sciences
Longitudinal imaging and quantitative genetic studies have both provided important insights
into the nature of human brain development. In the present study we combine these …
into the nature of human brain development. In the present study we combine these …
[HTML][HTML] Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
Neurodevelopmental disorders have a heritable component and are associated with region
specific alterations in brain anatomy. However, it is unclear how genetic risks for …
specific alterations in brain anatomy. However, it is unclear how genetic risks for …
Genetic complexity of cortical structure: differences in genetic and environmental factors influencing cortical surface area and thickness
Quantifying the genetic architecture of the cerebral cortex is necessary for understanding
disease and changes to the brain across the lifespan. Prior work shows that both surface …
disease and changes to the brain across the lifespan. Prior work shows that both surface …
Functional organization of the transcriptome in human brain
The enormous complexity of the human brain ultimately derives from a finite set of molecular
instructions encoded in the human genome. These instructions can be directly studied by …
instructions encoded in the human genome. These instructions can be directly studied by …
Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies
Choosing the appropriate neuroimaging phenotype is critical to successfully identify genes
that influence brain structure or function. While neuroimaging methods provide numerous …
that influence brain structure or function. While neuroimaging methods provide numerous …
[HTML][HTML] Where the genome meets the connectome: understanding how genes shape human brain connectivity
The integration of modern neuroimaging methods with genetically informative designs and
data can shed light on the molecular mechanisms underlying the structural and functional …
data can shed light on the molecular mechanisms underlying the structural and functional …