The discovery that alpha-synuclein (α-syn) is the primary component of the
neuropathological hallmarks of Parkinson's disease (PD) and the identification of α-syn …

Over the last two decades, many experimental and clinical studies have provided solid
evidence that alpha-synuclein (α-syn), a small, natively unfolded protein, is closely related to …

The aggregation of alpha synuclein (α‐syn) is a neuropathological feature that defines a
spectrum of disorders collectively termed synucleinopathies, and of these, Parkinson's …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder,
afflicting1% of individuals over the age of 65. PD results primarily from a severe and …

Alpha‐synuclein (α‐syn) is a small soluble protein expressed primarily at presynaptic
terminals in the central nervous system. Interest in α‐syn has increased dramatically after …

A better understanding of the molecular and cellular determinants that influence the
pathology of Parkinson's disease (PD) is essential for developing effective diagnostic …

There are currently no pharmacological treatments available that completely halt or reverse
the progression of Parkinson's Disease (PD). Hence, there is an unmet need for …

Several lines of evidence suggest that phosphorylation of α-synuclein (α-syn) at S87 or
S129 may play an important role in regulating its aggregation, fibrillogenesis, Lewy body …

Background: Parkinson's disease (PD) is a multifactorial, chronic, and progressive
neurodegenerative disease. α-Synuclein (α-syn), which is the main protein component of …

α-Synuclein (α-Syn) is a small cytosolic protein associated with a range of cellular
compartments, including synaptic vesicles, the nucleus, mitochondria, endoplasmic …