Although vascularized tissue-engineered bone grafts (TEBG) have been generated
ectopically in several studies, the use of prevascularized TEBG for segmental bone defect …

Although small animal model (rabbit) showed successful bone defect repair using
prevascularized tissue-engineered bone grafts (TEBG), large animal (rhesus monkey) …

Background Neovascularization is critical for bone regeneration. Numerous studies have
explored prevascularization preimplant strategies, ranging from calcium phosphate cement …

The regenerative repair of segmental bone defect (SBD) is an urgent problem in the field of
orthopedics. Rapid induction of angiogenesis and osteoinductivity after implantation of …

Background: Bone tissue defect, one of the common orthopaedicdiseases, is traumatizing
and affects patient's lifestyle. Although autologous and xenograft bone transplantations are …

Reconstruction of bone defects by tissue engineered substitutes requires coordinated
coupling between osteogenesis and angiogenesis. Basic fibroblast growth factor (bFGF or …

Management of segmental bone defects is a considerable challenge for orthopedic
surgeons. Tissue engineering is a promising method for repairing bone defects, and …

Bone is one of the most vascular network-rich tissues in the body and the vascular system is
essential for the development, homeostasis, and regeneration of bone. When segmental …

A major challenge in repairing large bone defects with tissue-engineered constructs is the
poor vascularization in the defect. The lack of vascular networks leads to insufficient oxygen …

Objective Bone regeneration involves a coordinated cascade of events that are regulated by
several cytokines and growth factors, among which bone morphogenic protein-2 (BMP-2) …