Progression of type 1 diabetes from latency to symptomatic disease is predicted by distinct autoimmune trajectories
Abstract Development of islet autoimmunity precedes the onset of type 1 diabetes in
children, however, the presence of autoantibodies does not necessarily lead to manifest …
children, however, the presence of autoantibodies does not necessarily lead to manifest …
A novel approach for the analysis of longitudinal profiles reveals delayed progression to type 1 diabetes in a subgroup of multiple-islet-autoantibody-positive children
D Endesfelder, M Hagen, C Winkler, F Haupt, S Zillmer… - Diabetologia, 2016 - Springer
Aims/hypothesis Progression to type 1 diabetes in children and adolescents is not uniform.
Based on individual genetic background and environment, islet autoimmunity may develop …
Based on individual genetic background and environment, islet autoimmunity may develop …
Stratifying risk for onset of type 1 diabetes using islet autoantibody trajectory clustering
Aims/hypothesis Islet autoantibodies can be detected prior to the onset of type 1 diabetes
and are important tools for aetiologic studies, prevention trials and disease screening …
and are important tools for aetiologic studies, prevention trials and disease screening …
Data-driven phenotyping of presymptomatic type 1 diabetes using longitudinal autoantibody profiles
OBJECTIVE To characterize distinct islet autoantibody profiles preceding stage 3 type 1
diabetes RESEARCH DESIGN AND METHODS The T1DI (Type 1 Diabetes Intelligence) …
diabetes RESEARCH DESIGN AND METHODS The T1DI (Type 1 Diabetes Intelligence) …
Transcriptional networks in at-risk individuals identify signatures of type 1 diabetes progression
LP Xhonneux, O Knight, Å Lernmark… - Science translational …, 2021 - science.org
Type 1 diabetes (T1D) is a disease of insulin deficiency that results from autoimmune
destruction of pancreatic islet β cells. The exact cause of T1D remains unknown, although …
destruction of pancreatic islet β cells. The exact cause of T1D remains unknown, although …
Time-resolved autoantibody profiling facilitates stratification of preclinical type 1 diabetes in children
Progression to clinical type 1 diabetes varies among children who develop β-cell
autoantibodies. Differences in autoantibody patterns could relate to disease progression …
autoantibodies. Differences in autoantibody patterns could relate to disease progression …
Continuous glucose monitoring predicts progression to diabetes in autoantibody positive children
AK Steck, F Dong, I Taki, M Hoffman… - The Journal of …, 2019 - academic.oup.com
Context Accurate measures are needed for the prediction and diagnosis of type 1 diabetes
(T1D) in at-risk persons. Objective The purpose of this study was to explore the value of …
(T1D) in at-risk persons. Objective The purpose of this study was to explore the value of …
Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection
Although the genetic basis and pathogenesis of type 1 diabetes have been studied
extensively, how host responses to environmental factors might contribute to autoantibody …
extensively, how host responses to environmental factors might contribute to autoantibody …
[HTML][HTML] A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes
Autoimmune-mediated destruction of pancreatic islet β cells results in type 1 diabetes (T1D).
Serum islet autoantibodies usually develop in genetically susceptible individuals in early …
Serum islet autoantibodies usually develop in genetically susceptible individuals in early …
Natural history of type 1 diabetes
P Achenbach, E Bonifacio, K Koczwara, AG Ziegler - Diabetes, 2005 - Am Diabetes Assoc
The natural history of autoimmune type 1 diabetes in children is associated with the
appearance of islet autoantibodies early in life, which is influenced by genetic and …
appearance of islet autoantibodies early in life, which is influenced by genetic and …