Quantitative, targeted analysis of gut microbiota derived metabolites provides novel biomarkers of early diabetic kidney disease in type 2 diabetes mellitus patients

L Balint, C Socaciu, AI Socaciu, A Vlad, F Gadalean… - Biomolecules, 2023 - mdpi.com
Diabetic kidney disease (DKD) is one of the most debilitating complications of type 2
diabetes mellitus (T2DM), as it progresses silently to end-stage renal disease (ESRD). The …

Current updates on metabolites and its interlinked pathways as biomarkers for diabetic kidney disease: a systematic review

S Das, D Rajeswari, G Venkataraman, R Elumalai… - Translational …, 2023 - Elsevier
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes mellitus
(DM) that poses a serious risk as it can lead to end-stage renal disease (ESRD). DKD is …

Characteristics of serum metabolites and gut microbiota in diabetic kidney disease

B Zhang, Y Wan, X Zhou, H Zhang, H Zhao… - Frontiers in …, 2022 - frontiersin.org
Disturbance of circulating metabolites and disorders of the gut microbiota are involved in the
progression of diabetic kidney disease (DKD). However, there is limited research on the …

Metabolite Profiling of the Gut–Renal–Cerebral Axis Reveals a Particular Pattern in Early Diabetic Kidney Disease in T2DM Patients

L Balint, C Socaciu, AI Socaciu, A Vlad… - International Journal of …, 2023 - mdpi.com
Type 2 diabetes mellitus (T2DM) represents an important microvascular disease concerning
the kidney and the brain. Gut dysbiosis and microbiota-derived metabolites may be in …

Gut microbiota profile and selected plasma metabolites in type 1 diabetes without and with stratification by albuminuria

SA Winther, P Henriksen, JK Vogt, TH Hansen… - Diabetologia, 2020 - Springer
Aims/hypothesis Abnormal gut microbiota and blood metabolome profiles have been
reported both in children and adults with uncomplicated type 1 diabetes as well as in adults …

The role of gut microbiota and microbiota-related serum metabolites in the progression of diabetic kidney disease

Q Zhang, Y Zhang, L Zeng, G Chen, L Zhang… - Frontiers in …, 2021 - frontiersin.org
Objective: Diabetic kidney disease (DKD) has become the major cause of end-stage renal
disease (ESRD) associated with the progression of renal fibrosis. As gut microbiota …

Roles of gut microbial metabolites in diabetic kidney disease

Q Fang, N Liu, B Zheng, F Guo, X Zeng… - Frontiers in …, 2021 - frontiersin.org
Diabetes is a highly prevalent metabolic disease that has emerged as a global challenge
due to its increasing prevalence and lack of sustainable treatment. Diabetic kidney disease …

Gut microbiota and its metabolites–molecular mechanisms and management strategies in diabetic kidney disease

ZH Mao, ZX Gao, DW Liu, ZS Liu, P Wu - Frontiers in immunology, 2023 - frontiersin.org
Diabetic kidney disease (DKD) is one of the major microvascular complications of diabetes
mellitus and is also one of the serious risk factors in cardiovascular events, end-stage renal …

Exploring the relevance between gut microbiota-metabolites profile and chronic kidney disease with distinct pathogenic factor

TH Chen, CY Cheng, CK Huang, YH Ho… - Microbiology …, 2023 - Am Soc Microbiol
The intimate correlation of chronic kidney disease (CKD) with structural alteration in gut
microbiota or metabolite profile has been documented in a growing body of studies …

Microbiome–metabolomics reveals gut microbiota associated with glycine-conjugated metabolites and polyamine metabolism in chronic kidney disease

YL Feng, G Cao, DQ Chen, ND Vaziri, L Chen… - Cellular and molecular …, 2019 - Springer
Dysbiosis of the gut microbiome and related metabolites in chronic kidney disease (CKD)
have been intimately associated with the prevalence of cardiovascular diseases …