Susceptibility to schizophrenia is inversely correlated with general cognitive ability at both
the phenotypic and the genetic level. Paradoxically, a modest but consistent positive genetic …

Synaptic plasticity alters the strength of information flow between presynaptic and
postsynaptic neurons and thus modifies the likelihood that action potentials in a presynaptic …

The genetic basis of schizophrenia has been a hotly debated research topic for decades, yet
recent studies, especially in the past year, have confirmed genetics as the major cause of …

Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …

Schizophrenia is a common multigenic and debilitating neurological disorder characterized
by chronic psychotic symptoms and psychosocial impairment. Complex interactions of …

Genetics constitute a crucial risk factor to schizophrenia. In the last decade, molecular
genetic research has produced novel findings, infusing optimism about discovering the …

Genome-wide association studies (GWAS) have identified a large number of gene variants
associated with schizophrenia, but these variants explain only a small portion of the …

The pathological mechanisms underlying schizophrenia are unclear. Although genetic
susceptibility factors for schizophrenia likely influence neurodevelopmental processes, the …

Multiple neurotransmitter circuits are disturbed in schizophrenia, and the dopamine
hypothesis of schizophrenia prevails as the hypothesis with most empirical support. On the …

Schizophrenia research has undergone a recent transformation. By leveraging large sample
sizes, genome-wide association studies of common genetic variants have approximately …