[PDF][PDF] Schizophrenia genetics comes of age
AC Need, DB Goldstein - Neuron, 2014 - cell.com
The new GWAS from the Schizophrenia Working Group of the Psychiatric Genomics
Consortium (2014) clearly validates a genetic approach to understanding schizophrenia …
Consortium (2014) clearly validates a genetic approach to understanding schizophrenia …
[HTML][HTML] Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia
Background While hybridization based analysis of the cortical transcriptome has provided
important insight into the neuropathology of schizophrenia, it represents a restricted view of …
important insight into the neuropathology of schizophrenia, it represents a restricted view of …
[HTML][HTML] Single-nuclei RNA sequencing of 5 regions of the human prenatal brain implicates developing neuron populations in genetic risk for schizophrenia
Background While a variety of evidence supports a prenatal component in schizophrenia,
there are few data regarding the cell populations involved. We sought to identify cells of the …
there are few data regarding the cell populations involved. We sought to identify cells of the …
The biological basis of schizophrenia: new directions
DR Weinberger - Journal of Clinical Psychiatry, 1997 - psychiatrist.com
The desire to understand the pathophysiology of schizophrenia has inspired an explosion in
research over the past decade. This review highlights some key studies that have led to …
research over the past decade. This review highlights some key studies that have led to …
Genome‐Wide Findings in Schizophrenia and the Role of Gene–Environment Interplay
R Van Winkel, G Esquivel, G Kenis… - CNS neuroscience & …, 2010 - Wiley Online Library
The recent advent of genome‐wide mass‐marker technology has resulted in renewed
optimism to unravel the genetic architecture of psychotic disorders. Genome‐wide …
optimism to unravel the genetic architecture of psychotic disorders. Genome‐wide …
Genes and environments in schizophrenia: the different pieces of a manifold puzzle
JM Réthelyi, J Benkovits, I Bitter - Neuroscience & Biobehavioral Reviews, 2013 - Elsevier
Genetic research targeting schizophrenia has undergone tremendous development during
recent years. Supported by recently developed high-throughput genotyping technologies …
recent years. Supported by recently developed high-throughput genotyping technologies …
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
[PDF][PDF] Phenotypic landscape of schizophrenia-associated genes defines candidates and their shared functions
Genomic studies have identified hundreds of candidate genes near loci associated with risk
for schizophrenia. To define candidates and their functions, we mutated zebrafish orthologs …
for schizophrenia. To define candidates and their functions, we mutated zebrafish orthologs …
[HTML][HTML] Common and rare genetic risk factors converge in protein interaction networks underlying schizophrenia
Hundreds of genomic loci have been identified with the recent advances of schizophrenia in
genome-wide association studies (GWAS) and sequencing studies. However, the functional …
genome-wide association studies (GWAS) and sequencing studies. However, the functional …
[HTML][HTML] From linkage studies to epigenetics: what we know and what we need to know in the neurobiology of schizophrenia
A Cariaga-Martinez, J Saiz-Ruiz… - Frontiers in …, 2016 - frontiersin.org
Schizophrenia is a complex psychiatric disorder characterized by the presence of positive,
negative, and cognitive symptoms that lacks a unifying neuropathology. In the present …
negative, and cognitive symptoms that lacks a unifying neuropathology. In the present …