Numerous studies have examined gene expression profiles in post-mortem human brain
samples from individuals with schizophrenia compared with healthy controls, to gain insight …

Identifying the genetic underpinnings of complex diseases offers insight into the etiological
mechanisms leading to manifestation of the disease. New and more effective treatments for …

Over 100 loci are now associated with schizophrenia risk as identified by single nucleotide
polymorphisms (SNPs) in genome-wide association studies. These findings mean that …

Background The quest to understand the neurobiology of schizophrenia and bipolar
disorder is ongoing with multiple lines of evidence indicating abnormalities of glia …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

Schizophrenia (SCZ) has a heritability of about 80%, and the search for the genetic basis of
this disease has been frustrating. Because schizophrenia has no distinguishing pathology or …

The clinically heterogeneous presentation of schizophrenia is compounded by the
heterogeneity of risk factors and neurobiological correlates of the disorder. Genome-wide …

Abstract Purpose of Review This is an era where we have significantly advanced the
understanding of the genetic architecture of schizophrenia. In this review, we consider how …

Highlights•Genetic analysis of schizophrenia and bipolar disorder is uncovering a wide
array of significant effects.•These results support a model of polygenic inheritance for both …

Epidemiological data favors genetic predisposition for schizophrenia, a common and
complex mental disorder in most populations. Search for the genes involved using …