[HTML][HTML] Endophenotypes in schizophrenia: digging deeper to identify genetic mechanisms
TA Greenwood, A Shutes-David… - Journal of psychiatry …, 2019 - ncbi.nlm.nih.gov
Schizophrenia (SZ) is a severe psychotic disorder that is highly heritable and common in the
general population. The genetic heterogeneity of SZ is substantial, with contributions from …
general population. The genetic heterogeneity of SZ is substantial, with contributions from …
What genes are differentially expressed in individuals with schizophrenia? A systematic review
AK Merikangas, M Shelly, A Knighton, N Kotler… - Molecular …, 2022 - nature.com
Schizophrenia is a severe, complex mental disorder characterized by a combination of
positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is …
positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is …
Neurobiology of schizophrenia
MF Egan, DR Weinberger - Current opinion in neurobiology, 1997 - Elsevier
Schizophrenia appears to bea neurodevelopmental disorder involving dysfunction prefrontal
and temporal cortical neural systems. Recent data implicate presynaptic changes in …
and temporal cortical neural systems. Recent data implicate presynaptic changes in …
The three-dimensional landscape of the genome in human brain tissue unveils regulatory mechanisms leading to schizophrenia risk
W Mah, H Won - Schizophrenia research, 2020 - Elsevier
Recent advances in our understanding of the genetic architecture of schizophrenia have
shed light on the schizophrenia etiology. While common variation is one of the major genetic …
shed light on the schizophrenia etiology. While common variation is one of the major genetic …
Neurodevelopmental disturbances in schizophrenia: evidence from genetic and environmental factors
Since more than 3 decades, schizophrenia (SZ) has been regarded as a
neurodevelopmental disorder. The neurodevelopmental hypothesis proposes that SZ is …
neurodevelopmental disorder. The neurodevelopmental hypothesis proposes that SZ is …
Glutamate networks implicate cognitive impairments in schizophrenia: genome-wide association studies of 52 cognitive phenotypes
K Ohi, R Hashimoto, M Ikeda, H Yamamori… - Schizophrenia …, 2015 - academic.oup.com
Cognitive impairments are a core feature in patients with schizophrenia. These deficits could
serve as effective tools for understanding the genetic architecture of schizophrenia. This …
serve as effective tools for understanding the genetic architecture of schizophrenia. This …
Association between polygenic risk for schizophrenia, neurocognition and social cognition across development
Breakthroughs in genomics have begun to unravel the genetic architecture of schizophrenia
risk, providing methods for quantifying schizophrenia polygenic risk based on common …
risk, providing methods for quantifying schizophrenia polygenic risk based on common …
Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia
Schizophrenia is a devastating neurodevelopmental disorder with a complex genetic
etiology. Widespread cortical gray matter loss has been observed in patients and prodromal …
etiology. Widespread cortical gray matter loss has been observed in patients and prodromal …
Neural mechanisms of a genome-wide supported psychosis variant
Schizophrenia is a devastating, highly heritable brain disorder of unknown etiology.
Recently, the first common genetic variant associated on a genome-wide level with …
Recently, the first common genetic variant associated on a genome-wide level with …
Synaptic changes in the brain of subjects with schizophrenia
G Faludi, K Mirnics - International Journal of Developmental Neuroscience, 2011 - Elsevier
Clinical, epidemiological, neuroimaging and postmortem data all suggest schizophrenia is a
neurodevelopmental disorder, and that synaptic disturbances might play a critical role in …
neurodevelopmental disorder, and that synaptic disturbances might play a critical role in …