A review of molecular genetic studies of neurocognitive deficits in schizophrenia
Schizophrenia is a complex and debilitating illness with strong genetic loading. In line with
its heterogeneous symptomatology, evidence suggests genetic etiologies for the …
its heterogeneous symptomatology, evidence suggests genetic etiologies for the …
Strong synaptic transmission impact by copy number variations in schizophrenia
JT Glessner, MP Reilly, CE Kim… - Proceedings of the …, 2010 - National Acad Sciences
Schizophrenia is a psychiatric disorder with onset in late adolescence and unclear etiology
characterized by both positive and negative symptoms, as well as cognitive deficits. To …
characterized by both positive and negative symptoms, as well as cognitive deficits. To …
[PDF][PDF] Novel findings from CNVs implicate inhibitory and excitatory signaling complexes in schizophrenia
AJ Pocklington, E Rees, JTR Walters, J Han… - Neuron, 2015 - cell.com
We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the
association between the disorder and chromosomal copy number (CNV) burden. We …
association between the disorder and chromosomal copy number (CNV) burden. We …
What next in schizophrenia genetics for the psychiatric genomics consortium?
A Corvin, PF Sullivan - Schizophrenia bulletin, 2016 - academic.oup.com
Over the last 8 years the Psychiatric Genomics Consortium (PGC; http://pgc. unc. edu) has
fundamentally changed the landscape for psychiatric genetics research. This has been …
fundamentally changed the landscape for psychiatric genetics research. This has been …
[HTML][HTML] The synaptic pruning hypothesis of schizophrenia: promises and challenges
Recent genome-wide association studies in large samples have revealed 108 genetic loci
significantly associated with the risk of the disorder. The strongest risk was repeatedly …
significantly associated with the risk of the disorder. The strongest risk was repeatedly …
Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and …
CJ Carter - Schizophrenia research, 2006 - Elsevier
Over 130 genes have been associated with schizophrenia in genetic studies. None of these
has reached a sufficient level of confidence to be accepted as a universal susceptibility gene …
has reached a sufficient level of confidence to be accepted as a universal susceptibility gene …
Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission
Schizophrenia affects approximately 1% of the world population. Genetics, epigenetics, and
environmental factors are known to play a role in this psychiatric disorder. While there is a …
environmental factors are known to play a role in this psychiatric disorder. While there is a …
A role for noncoding variation in schizophrenia
A large portion of common variant loci associated with genetic risk for schizophrenia reside
within noncoding sequence of unknown function. Here, we demonstrate promoter and …
within noncoding sequence of unknown function. Here, we demonstrate promoter and …
Alteration of neuronal excitability and short-term synaptic plasticity in the prefrontal cortex of a mouse model of mental illness
GW Crabtree, Z Sun, M Kvajo, JAC Broek… - Journal of …, 2017 - Soc Neuroscience
Using a genetic mouse model that faithfully recapitulates a DISC1 genetic alteration strongly
associated with schizophrenia and other psychiatric disorders, we examined the impact of …
associated with schizophrenia and other psychiatric disorders, we examined the impact of …
Multifaceted genomic risk for brain function in schizophrenia
Recently, deriving candidate endophenotypes from brain imaging data has become a
valuable approach to study genetic influences on schizophrenia (SZ), whose …
valuable approach to study genetic influences on schizophrenia (SZ), whose …