Long periods of skeletal muscle inactivity promote a loss of muscle protein resulting in fiber
atrophy. This disuse-induced muscle atrophy results from decreased protein synthesis and …

Skeletal muscles comprise the largest organ system in the body and play an essential role in
body movement, breathing, and glucose homeostasis. Skeletal muscle is also an important …

Prolonged periods of skeletal muscle inactivity lead to a loss of muscle protein and strength.
Advances in cell biology have progressed our understanding of those factors that contribute …

Muscle mass and strength are very important for exercise performance. Training-induced
musculoskeletal injuries usually require periods of complete immobilization to prevent any …

Skeletal muscle inactivity is associated with a loss of muscle protein and reduced force-
generating capacity. This disuse-induced muscle atrophy results from both increased …

Although it is established that oxidants can participate in the regulation of protein turnover in
cells, there remains debate as to whether oxidative stress is required for disuse skeletal …

Oxidative stress, inflammation, mitochondrial dysfunction, reduced protein synthesis, and
increased proteolysis are all critical factors in the process of muscle atrophy. In particular …

Changes in the skeletal muscle protein mass frequently occur in both physiological and
pathological states. Muscle hypotrophy, in particular, is commonly observed during aging …

Significance: Skeletal muscles play essential roles in key body functions including
breathing, locomotion, and glucose homeostasis; therefore, maintaining healthy skeletal …

A pivotal role has been ascribed to oxidative stress in determining the imbalance between
protein synthesis and degradation leading to muscle atrophy in many pathological …