Objective Infection with the novel coronavirus SARS–CoV‐2 triggers severe illness with high
mortality in a subgroup of patients. Such a critical course of COVID‐19 is thought to be …

Poor outcomes in COVID‐19 correlate with clinical and laboratory features of cytokine storm
syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy …

Objectives To develop predictive criteria for COVID-19-associated cytokine storm (CS), a
severe hyperimmune response that results in organ damage in some patients infected with …

Hyperinflammation is a key component of severe COVID-19, residing underneath the
cytokine storm umbrella term, associated with poor outcomes. Better understanding of the …

The clinical progression of the severe acute respiratory syndrome coronavirus 2 infection,
coronavirus 2019 (COVID‐19), to critical illness is associated with an exaggerated immune …

Objective A critical role in coronavirus disease 2019 (COVID-19) pathogenesis is played by
immune dysregulation that leads to a generalized uncontrolled multisystem inflammatory …

Cytokine storm is an umbrella term that describes an inflammatory syndrome characterized
by elevated levels of circulating cytokines and hyperactivation of innate and/or adaptive …

Background In these first months of coronavirus disease-19 (COVID-19) pandemic, a
mainstream pathogenetic hypothesis, likely stemming from early clinico-therapeutic …

Although interest in “cytokine storms” has surged over the past decade, it was massively
amplified in 2020 when it was suggested that a subset of patients with COVID-19 developed …

Background SARS-CoV-2 has been responsible for considerable mortality worldwide, owing
in particular to pulmonary failures such as ARDS, but also to other visceral failures and …