Macrophages promote an early host response to infection by releasing pro-inflammatory
cytokines such as interleukin-1β (IL-1β), TNF, and IL-6. The bioactivity of IL-1β is classically …

Inflammation observed in SARS-CoV-2-infected patients suggests that inflammasomes,
proinflammatory intracellular complexes, regulate various steps of infection. Lung epithelial …

A recent mutation analysis suggested that Non-Structural Protein 6 (NSP6) of the Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant of the viral …

A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …

Severe SARS-CoV-2 infection causes systemic inflammation, cytokine storm, and
hypercytokinemia due to activation of the release of pro-inflammatory cytokines that have …

Nod-like receptor family, pyrin domain-containing 3 (NLRP3) regulates the secretion of
proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. We previously showed that …

Coronaviruses have caused several zoonotic infections in the past two decades, leading to
significant morbidity and mortality globally. Balanced regulation of cell death and …

Most COVID-19 infected individuals present with mild flu-like symptoms; however, 5–10% of
cases suffer from life-threatening pneumonia and respiratory failure. The pathogenesis of …

SARS-CoV-2 might directly activate NLRP3 inflammasome resulting in an endogenous
adjuvant activity necessary to mount a proper adaptive immune response against the virus …

The world has witnessed a high morbidity and mortality caused by SARS-CoV-2, and global
death toll is still rising. Exaggerated inflammatory responses are thought to be more …