Despite the introduction of vaccines and drugs for SARS-CoV-2, the COVID-19 pandemic
continues to spread throughout the world. In severe COVID-19 patients, elevated levels of …

Background Infection of SARS-CoV-2 may cause acute respiratory syndrome. It has been
reported that SARS-CoV-2 nucleocapsid protein (N-protein) presents early in body fluids …

Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine
production, viral RNA and a sustained interferon (IFN) response, all of which are …

Elevated levels of cytokines IL-1β and IL-6 are associated with severe COVID-19.
Investigating the underlying mechanisms, we find that while primary human airway epithelia …

The NLR pyrin domain containing 3 (NLRP3) inflammasome is a major component of the
innate immune system, but its mechanism of activation by a wide range of molecules …

Objective The orf8b protein of the coronavirus SARS-CoV, analogous to SARS-CoV-2,
triggers the NLRP3 inflammasome in macrophages in vitro. Deregulated inflammasome …

Inflammasomes are multi-protein complexes that trigger the activation of caspase-1 and the
maturation of interleukin-1β (IL-1β), yet the regulation of these complexes remains poorly …

Severe acute respiratory syndrome coronavirus (SARS-CoV) is capable of inducing a storm
of proinflammatory cytokines. In this study, we show that the SARS-CoV open reading frame …

Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) engages
the inflammasome in monocytes and macrophages and leads to the cytokine storm in …

COVID-19 which is caused by severe acute respiratory syndrome coronavirus (SARS-CoV-
2) has posed a worldwide pandemic and a major global public health threat. SARS-CoV-2 …