Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to shutoff of protein
synthesis, and nsp1, a central shutoff factor in coronaviruses, inhibits cellular mRNA …

The inflammasome is a molecular platform that stimulates the activation of caspase-1 and
the processing of pro-interleukin (IL)-1β and pro-IL-18 for secretion. The NOD-like receptor …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces mild or
asymptomatic COVID-19 in most cases, but some patients develop an excessive …

Curcumin is the effective ingredient of turmeric, sometimes used as a painkiller in traditional
medicine. It has extensive biological properties such as anti‐inflammatory and antioxidant …

NLRP3 is the best characterized cytosolic nod-like pattern recognition receptor which can
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to …

As an important transcription factor, heat shock factor 1 (HSF1) plays an endogenous anti-
inflammation role in the body and can alleviate multiple organ dysfunction caused by sepsis …

The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …

SARS-CoV-2 causes acute respiratory distress that can progress to multiorgan failure and
death in a minority of patients. Although severe COVID-19 disease is linked to exuberant …

Coronavirus disease 2019 (COVID-19) is the most devastating infectious disease in the 21st
century with more than 2 million lives lost in less than a year. The activation of …

Despite global vaccination programs, infections with severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) continue to cause severe disease with significant morbidity …