Inflammasomes are multiprotein complexes that drive inflammation and contribute to
protective immunity against pathogens and immune pathology in autoinflammatory …

Almost all human diseases are strongly associated with inflammation, and a deep
understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome …

Background Compared to healthy controls, severe COVID19 patients display increased
levels of activated NLRP3-inflammasome (NLRP3-I) and interleukin (IL)-1β. SARS-CoV-2 …

Gram-positive bacteria, including Staphylococcus aureus are endemic in the US, which
cause life-threatening necrotizing pneumonia. Neutrophils are known to be critical for …

Coronaviruses (CoVs) are members of the genus Betacoronavirus and the Coronaviridiae
family responsible for infections such as severe acute respiratory syndrome (SARS), Middle …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is capable of inducing the
activation of NACHT, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) …

The NLRP3 inflammasome is a multi-molecular complex that acts as a molecular platform to
mediate caspase-1 activation, leading to IL-1β/IL-18 maturation and release in cells …

While the molecular mechanisms promoting activation of the Nod-like Receptor (NLR) family
member NLRP3 inflammasome are beginning to be defined, little is known about the …

Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern
recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns …