Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades most innate
immune responses but may still be vulnerable to some. Here, we systematically analyze the …

Inflammasomes are high molecular weight protein complexes that assemble in the cytosol
upon pathogen encounter. This results in caspase-1-dependent pro-inflammatory cytokine …

The inflammatory response to severe acute respiratory syndrome–related coronavirus 2
infection has a direct impact on the clinical outcomes of coronavirus disease 2019 patients …

Excessive inflammatory responses contribute to the pathogenesis and lethality of highly
pathogenic human coronaviruses, but the underlying mechanism remains unclear. In this …

Specifically designed and functionalized nanoparticles hold great promise for biomedical
applications. Yet, the applicability of nanoparticles is critically predetermined by their surface …

ABSTRACT NLRP3 inflammasome mainly controls interleukin-1β (IL-1β) secretion, leading
to cell death called pyroptosis constituting a major antiviral host defense and inflammatory …

The cytosolic pattern recognition receptor (PRR) NOD-like receptor family, pyrin domain
containing 3 (NLRP3) senses a wide range of pathogen-associated molecular patterns …

Cardiovascular diseases (CVDs) are the prevalent cause of mortality around the world.
Activation of inflammasome contributes to the pathological progression of cardiovascular …

Background NLRP3 inflammasome is involved in the inflammatory responses during acute
lung injury (ALI). RIP3 triggered NLRP3 inflammasome activation independent of …

The genome of SARS-CoV-2 encodes two viral proteases (NSP3/papain-like protease and
NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during …