Epithelial organ morphogenesis involves sequential acquisition of apicobasal polarity by
epithelial cells and development of a functional lumen. In vivo, cells perceive signals from …

Highlights•Epithelial morphogenesis responds to mechanotransduction.•Suppression of
actin contractility is a cue for establishing epithelial polarity.•Collective angular migration …

The morphogenesis of developing tissues relies on extensive cellular rearrangements in
shape, position, and identity. A key process in reshaping tissues is cell intercalation-driven …

Control of the establishment of cell polarity is an essential function in tissue morphogenesis
and renewal that depends on spatial cues provided by the extracellular environment. The …

Regulation of cell growth and cell division has a fundamental role in tissue formation, organ
development, and cancer progression. Remarkable similarities in the topological …

Tissue morphogenesis requires the coordinated regulation of cellular behavior, which
includes the orientation of cell division that defines the position of daughter cells in the …

Patterning of developing tissues arises from a number of mechanisms, including cell shape
change, cell proliferation, and cell sorting from differential cohesion or tension. Here, we …

The de novo formation of secretory lumens plays an important role during organogenesis. It
involves the establishment of a cellular apical pole and the elongation of luminal cavities …

Many organs consist of tubes of epithelial cells enclosing a central lumen. How the space of
this lumen is generated is a key question in morphogenesis. Two predominant mechanisms …

The growth of a well-formed epithelial structure is governed by mechanical constraints,
cellular apico-basal polarity, and spatially controlled cell division. Here we compared the …