In this paper we describe the synthesis, physicochemical characteristics and data on the
biological activity of polymer prodrugs based on the anticancer drugs paclitaxel (PTX) and …

Purpose In vivo efficacy and safety of HPMA-based copolymers armed with doxorubicin via
a spacer containing pH-sensitive linkage that can be prepared within a broad range of …

Three maleimide derivatives of the anticancer drug paclitaxel that incorporate an acid-
sensitive carboxylic hydrazone linker were prepared and coupled to bifunctional PEGs (MW …

Various conjugates of anticancer drug doxorubicin (DOX) covalently attached via
hydrolytically degradable hydrazone bond to water-soluble N-(2-hydroxypropyl) …

In this paper we describe the synthesis, physico-chemical characteristics and results of tests
of biological activity of polymer drugs based on conjugates of anti-cancer drug doxorubicin …

An amphiphilic polymer-drug conjugate was prepared by attachment of low molecular
weight methoxy poly (ethylene glycol)(PEG)(ie, 2 kDa) to docetaxel (DTX) through an ester …

Data on the synthesis, physicochemical characterisation and in vitro and in vivo biological
properties of the new, nontargeted or antibody-targeted polymer–doxorubicin conjugates …

Conclusions These data describing the preclinical and early clinical development of CT-
2103 demonstrate the feasibility of using polyglutamic acid homopolymers to create …

The performance and safety of current antineoplastic agents, particularly water-insoluble
drugs, are still far from satisfactory. For example, the currently widely used Cremophor EL® …

Targeted drug delivery aims to increase the therapeutic index by making more drug
molecules available at the diseased sites while reducing systemic drug exposure. In this …