Oxidative stress contributes to the pathogenesis of diabetic nephropathy (DN). Nuclear
factor erythroid 2-related factor 2 (NRF2) plays a key role in cellular defense against …

Abstract The Nrf2/Keap1 system regulates the transcription of antioxidant and cytoprotective
genes through direct Nrf2 binding to responsive elements in the promoter region of target …

Evidence suggests that the glycogen synthase kinase 3 (GSK3)–dictated nuclear exclusion
and degradation of Nrf2 is pivotal in switching off the self-protective antioxidant stress …

Background Nuclear factor erythroid 2-related factor 2 (Nrf2) is a central mediator of cellular
responses to oxidative stress. We hypothesized that Nrf2 modulates progression from acute …

Massive intravascular hemolysis is associated with acute kidney injury (AKI). Nuclear factor
erythroid-2-related factor 2 (Nrf2) plays a central role in the defense against oxidative stress …

The cytoprotective transcriptor factor nuclear factor erythroid 2–related factor 2 (NRF2) is
part of a complex regulatory network that responds to environmental cues. To better …

The mainstay of therapy for chronic kidney disease is control of blood pressure and
proteinuria through the use of angiotensin-converting enzyme inhibitors (ACE-Is) or …

Diabetic nephropathy (DN) is one of the major complications in diabetes patients. Reactive
oxygen species (ROS) play key roles in DN progression. As a primary transcription factor …

Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor that controls cellular
defense responses against toxic and oxidative stress by modulating the expression of genes …

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …