The neovascularization of three‐dimensional voluminous tissues, such as bone, represents
an important challenge in tissue engineering applications. The formation of a preformed …

The development of technologies to promote vascularization of engineered tissue would
drive major developments in tissue engineering and regenerative medicine. Recently, we …

To engineer tissues with clinically relevant dimensions, one must overcome the challenge of
rapidly creating functional blood vessels to supply cells with oxygen and nutrients and to …

One of the major challenges in tissue engineering of bone substitutes remains
vascularization of the transplant. We have developed a three-dimensional collagen-based …

Currently, most in vitro engineered bone tissues do not contain viable blood vessel systems,
so the vascularization depends on post-implantation angiogenesis from the host, which is …

Significant bone loss due to disease or traumatic injury requires surgical intervention to
modulate the natural healing process of bone. The current bone grafting options, autografts …

Engraftment of tissue-engineered bone plays a pivotal role in the treatment of large bone
defects. However, promoting thorough vascularization in the central area of tissue …

Addressing the problem of vascularization is of vital importance when engineering three-
dimensional (3D) tissues. Endothelial cells are increasingly used in tissue-engineered …

The repair of bone defects remains a major clinical challenge because none available
reconstruction methods and biomaterials have been proved completely satisfactory. As a …

Tissue engineering provides unique opportunities for regenerating diseased or damaged
tissues using cells obtained from tissue biopsies. Tissue engineered grafts can also be used …