Potential anti-SARS-CoV-2 therapeutics that target the post-entry stages of the viral life cycle: A comprehensive review

RA Al-Horani, S Kar - Viruses, 2020 - mdpi.com
The coronavirus disease-2019 (COVID-19) pandemic continues to challenge health care
systems around the world. Scientists and pharmaceutical companies have promptly …

Potential anti-COVID-19 therapeutics that block the early stage of the viral life cycle: structures, mechanisms, and clinical trials

RA Al-Horani, S Kar, KF Aliter - International Journal of Molecular …, 2020 - mdpi.com
The ongoing pandemic of coronavirus disease-2019 (COVID-19) is being caused by severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The disease continues to present …

[HTML][HTML] Mechanism of action of small-molecule agents in ongoing clinical trials for SARS-CoV-2: a review

L Zhao, S Li, W Zhong - Frontiers in Pharmacology, 2022 - frontiersin.org
Since the first reports from December 2019, COVID-19 caused an overwhelming global
pandemic that has affected 223 countries, seriously endangering public health and creating …

Druggable targets of SARS-CoV-2 and treatment opportunities for COVID-19

BK Kumar, KVGC Sekhar, S Kunjiappan, J Jamalis… - Bioorganic …, 2020 - Elsevier
COVID-19 caused by the novel SARS-CoV-2 has been declared a pandemic by the WHO is
causing havoc across the entire world. As of May end, about 6 million people have been …

Drug targets for COVID-19 therapeutics: Ongoing global efforts

A Saxena - Journal of biosciences, 2020 - Springer
The current global pandemic COVID-19 caused by the SARS-CoV-2 virus has already
inflicted insurmountable damage both to the human lives and global economy. There is an …

[PDF][PDF] Chemistry and biology of SARS-CoV-2

A Dömling, L Gao - Chem, 2020 - cell.com
Summary SARS-CoV-2 (previously 2019-nCoV or Wuhan coronavirus) caused an
unprecedented fast-spreading worldwide pandemic. Although currently with a rather low …

The recent outbreaks of human coronaviruses: A medicinal chemistry perspective

T Pillaiyar, LL Wendt, M Manickam… - Medicinal research …, 2021 - Wiley Online Library
Coronaviruses (CoVs) infect both humans and animals. In humans, CoVs can cause
respiratory, kidney, heart, brain, and intestinal infections that can range from mild to lethal …

[HTML][HTML] Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors

S Gao, T Huang, L Song, S Xu, Y Cheng… - … Pharmaceutica Sinica B, 2022 - Elsevier
Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection.
Herein, we briefly provide a concise report on the medicinal chemistry strategies towards the …

Strategies for targeting sars cov-2: Small molecule inhibitors—The current status

NM Beeraka, SP Sadhu… - Frontiers in …, 2020 - frontiersin.org
Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2) induced Coronavirus
Disease-19 (COVID-19) cases have been increasing at an alarming rate (7.4 million positive …

[HTML][HTML] Recent advances in developing small-molecule inhibitors against SARS-CoV-2

R Xiang, Z Yu, Y Wang, L Wang, S Huo, Y Li… - … Pharmaceutica Sinica B, 2022 - Elsevier
The COVID-19 pandemic caused by the novel SARS-CoV-2 virus has caused havoc across
the entire world. Even though several COVID-19 vaccines are currently in distribution …