[HTML][HTML] Virtual screening of natural metabolites and antiviral drugs with potential inhibitory activity against 3CL-PRO and PL-PRO

N Contreras-Puentes… - Biomedical and …, 2020 - biomedpharmajournal.org
Aims: COVID-19 is a global pandemic that has affected around 186 countries in the world,
related to clinical signs as fever, cough and pneumonia. The disease is caused by SARS …

A comprehensive review on promising anti-viral therapeutic candidates identified against main protease from SARS-CoV-2 through various computational methods

E Singh, RJ Khan, RK Jha, GM Amera, M Jain… - Journal of Genetic …, 2020 - Elsevier
Background The COVID-19 pandemic caused by SARS-CoV-2 has shown an exponential
trend of infected people across the planet. Crediting its virulent nature, it becomes …

Identification of potential inhibitors of three key enzymes of SARS-CoV2 using computational approach

H Iftikhar, HN Ali, S Farooq, H Naveed… - Computers in biology …, 2020 - Elsevier
The recent outbreak of coronavirus disease-19 (COVID-19) continues to drastically affect
healthcare throughout the world. To date, no approved treatment regimen or vaccine is …

Natural compounds as inhibitors of SARS-CoV-2 main protease (3CLpro): A molecular docking and simulation approach to combat COVID-19

MT Rehman, MF AlAjmi… - Current pharmaceutical …, 2021 - ingentaconnect.com
Background: The emergence and dissemination of SARS-CoV-2 has caused high mortality
and enormous economic loss. Rapid development of new drug molecules is the need of …

Virtual high throughput screening: Potential inhibitors for SARS-CoV-2 PLPRO and 3CLPRO proteases

D Jade, S Ayyamperumal, V Tallapaneni… - European journal of …, 2021 - Elsevier
Abstract The pandemic, COVID-19, has spread worldwide and affected millions of people.
There is an urgent need, therefore, to find a proper treatment for the novel coronavirus …

Molecular docking of olea europaea and curcuma longa compounds as potential drug agents for targeting main-protease of SARS-nCoV2

R Saif, MH Raza, T Rehman, MO Zafar, S Zia… - 2020 - chemrxiv.org
One of the main reasons of rapidly growing cases of COVID-19 pandemic is the
unavailability of approved therapeutic agents. Therefore, it is urgently required to find out the …

[HTML][HTML] Potential inhibitors of SARS-CoV-2 (COVID 19) proteases PLpro and Mpro/3CLpro: molecular docking and simulation studies of three pertinent medicinal …

D Verma, D Mitra, M Paul, P Chaudhary… - Current Research in …, 2021 - Elsevier
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-
coronavirus disease 2019 (COVID-19) has raised a severe global public health issue and …

Identification of nafamostat and VR23 as COVID-19 drug candidates by targeting 3CLpro and PLpro

D Bhowmik, RD Sharma, A Prakash… - Journal of molecular …, 2021 - Elsevier
The sudden increase in the COVID-19 epidemic affected by novel coronavirus 2019 has
jeopardized public health worldwide. Hence the necessities of a drug or therapeutic agent …

[HTML][HTML] Structure-based virtual screening of phytochemicals and repurposing of FDA approved antiviral drugs unravels lead molecules as potential inhibitors of …

AB Gurung, MA Ali, J Lee, MA Farah… - Journal of King Saud …, 2020 - Elsevier
Coronaviruses are enveloped positive-strand RNA viruses belonging to family
Coronaviridae and order Nidovirales which cause infections in birds and mammals. Among …

[HTML][HTML] Repurposing of known anti-virals as potential inhibitors for SARS-CoV-2 main protease using molecular docking analysis

M Hakmi, EM Bouricha, I Kandoussi, J El Harti… - …, 2020 - ncbi.nlm.nih.gov
The new SARS-CoV-2 coronavirus is the causative agent of the COVID-19 pandemic
outbreak that affected more than 190 countries worldwide with more than 292,000 confirmed …