Neuroscience in the era of functional genomics and systems biology

DH Geschwind, G Konopka - Nature, 2009 - nature.com
Advances in genetics and genomics have fuelled a revolution in discovery-based, or
hypothesis-generating, research that provides a powerful complement to the more directly …

Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders

NN Parikshak, MJ Gandal, DH Geschwind - Nature Reviews Genetics, 2015 - nature.com
Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …

Neurogenomics: at the intersection of neurobiology and genome sciences

MS Boguski, AR Jones - Nature neuroscience, 2004 - nature.com
Neurogenomics is the study of how the genome as a whole contributes to the evolution,
development, structure and function of the nervous system. It includes investigations of how …

Neurogenetics: advancing the “next-generation” of brain research

HY Zoghbi, ST Warren - Neuron, 2010 - cell.com
There can be little doubt that genetics has transformed our understanding of mechanisms
mediating brain disorders. The last two decades have brought tremendous progress in terms …

Molecular genetics and imaging technologies for circuit-based neuroanatomy

BR Arenkiel, MD Ehlers - Nature, 2009 - nature.com
Brain function emerges from the morphologies, spatial organization and patterns of
connectivity established between diverse sets of neurons. Historically, the notion that …

Advancements in the quest to map, monitor, and manipulate neural circuitry

JL Swanson, PS Chin, JM Romero… - Frontiers in Neural …, 2022 - frontiersin.org
Neural circuits and the cells that comprise them represent the functional units of the brain.
Circuits relay and process sensory information, maintain homeostasis, drive behaviors, and …

Putting big data to good use in neuroscience

TJ Sejnowski, PS Churchland, JA Movshon - Nature neuroscience, 2014 - nature.com
Big data has transformed fields such as physics and genomics. Neuroscience is set to
collect its own big data sets, but to exploit its full potential, there need to be ways to …

Genetic approaches to neural circuits in the mouse

Z Josh Huang, H Zeng - Annual review of neuroscience, 2013 - annualreviews.org
To understand the organization and assembly of mammalian brain circuits, we need a
comprehensive tool set that can address the challenges of cellular diversity, spatial …

Challenges and opportunities in mining neuroscience data

H Akil, ME Martone, DC Van Essen - science, 2011 - science.org
Understanding the brain requires a broad range of approaches and methods from the
domains of biology, psychology, chemistry, physics, and mathematics. The fundamental …

The data science future of neuroscience theory

B Voytek - Nature methods, 2022 - nature.com
The data science future of neuroscience theory | Nature Methods Skip to main content Thank
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