Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma

D Gentien, E Saberi-Ansari, N Servant, A Jolly… - Cell reports, 2023 - cell.com
Uveal melanoma (UM) is a rare cancer resulting from the transformation of melanocytes in
the uveal tract. Integrative analysis has identified four molecular and clinical subsets of UM …

[HTML][HTML] Heterogeneity revealed by integrated genomic analysis uncovers a molecular switch in malignant uveal melanoma

MJ de Lange, SI van Pelt, M Versluis, ES Jordanova… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Gene expression profiles as well as genomic imbalances are correlated with disease
progression in uveal melanoma (UM). We integrated expression and genomic profiles to …

Emerging insights into the molecular pathogenesis of uveal melanoma

S Landreville, OA Agapova, JW Harbour - Future oncology, 2008 - Taylor & Francis
Uveal melanoma is the most common primary cancer of the eye, and often results not only in
vision loss, but also in metastatic death in up to half of patients. For many years, the details …

Emerging therapeutic opportunities based on current knowledge of uveal melanoma biology

R Vivet-Noguer, M Tarin, S Roman-Roman, S Alsafadi - Cancers, 2019 - mdpi.com
Uveal Melanoma (UM) is a rare and malignant intraocular tumor with dismal prognosis.
Despite the efficient control of the primary tumor by radiation or surgery, up to 50% of …

[HTML][HTML] Repression of genes involved in melanocyte differentiation in uveal melanoma

MA Bergeron, S Champagne, M Gaudreault… - Molecular …, 2012 - ncbi.nlm.nih.gov
Purpose Uveal melanoma (UM) has been the subject of intense interest due to its distinctive
metastatic pattern, which involves hematogenous dissemination of cancerous cells toward …

A comparative transcriptomic analysis of uveal melanoma and normal uveal melanocyte

J An, H Wan, X Zhou, DN Hu, L Wang, L Hao, D Yan… - PLoS …, 2011 - journals.plos.org
Background Uveal melanoma is the most common primary intraocular tumor in adults in
western countries. It is associated with very severe visual morbidity and may lead to distant …

Genetic and Epigenetic Features of Uveal Melanoma—An Overview and Clinical Implications

D Pašalić, T Nikuševa-Martić, A Sekovanić… - International journal of …, 2023 - mdpi.com
Uveal melanoma (UM) is rare, but it is the most common primary intraocular malignancy
among adults. This review represents the molecular, genetic, and immunobiological …

Applying single-cell technology in uveal melanomas: current trends and perspectives for improving uveal melanoma metastasis surveillance and tumor profiling

MM Wang, C Chen, MN Lynn, CR Figueiredo… - Frontiers in Molecular …, 2021 - frontiersin.org
Uveal melanoma (UM) is the most common primary adult intraocular malignancy. This rare
but devastating cancer causes vision loss and confers a poor survival rate due to distant …

New insights into molecular oncogenesis and therapy of uveal melanoma

SS Violanti, I Bononi, CE Gallenga, F Martini… - Cancers, 2019 - mdpi.com
Uveal melanoma (UM), which is the most common cancer of the eye, was investigated in
recent years by many teams in the field of biomedical sciences and eye clinicians. New …

Clinicopathological and prognostic significance and molecular mechanisms governing uveal melanoma

MY Wu, TT Lai, WT Liao, CJ Li - Therapeutic Advances in …, 2020 - journals.sagepub.com
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults.
Although UM and cutaneous melanoma are derived from melanocytes, UM differs clinically …