Precision Medicine in Cardiovascular Disease: Genetics and Impact on Phenotypes: JACC Focus Seminar 1/5

C Semsarian, J Ingles, SB Ross, SL Dunwoodie… - Journal of the American …, 2021 - jacc.org
Our understanding of the genetic basis of cardiovascular diseases (CVDs) has evolved
rapidly. This has resulted from a combination of dedicated research in well phenotyped CVD …

Cardiovascular precision medicine in the genomics era

AM Dainis, EA Ashley - JACC: Basic to Translational Science, 2018 - jacc.org
Precision medicine strives to delineate disease using multiple data sources—from genomics
to digital health metrics—in order to be more precise and accurate in our diagnoses …

Epigenetics and precision medicine in cardiovascular patients: from basic concepts to the clinical arena

S Costantino, P Libby, R Kishore, JC Tardif… - European heart …, 2018 - academic.oup.com
Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide and also
inflict major burdens on morbidity, quality of life, and societal costs. Considering that CVD …

Exploring predisposition and treatment response—the promise of genomics

S Pan, JW Knowles - Progress in cardiovascular diseases, 2012 - Elsevier
Spurred by large-scale public and private efforts as well as technological developments, the
last few years have seen a major leap forward in our understanding of the genetic basis of …

Cardiovascular genomics, personalized medicine, and the National Heart, Lung, and Blood Institute: part I: the beginning of an era

CJ O'Donnell, EG Nabel - Circulation: Cardiovascular Genetics, 2008 - Am Heart Assoc
The inaugural issue of Circulation: Cardiovascular Ge-netics arrives at a remarkable time in
the history of genetic research and cardiovascular medicine. Despite tremendous progress …

Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association

CS Fox, JL Hall, DK Arnett, EA Ashley, C Delles… - Circulation, 2015 - Am Heart Assoc
The field of genetics and genomics has advanced considerably with the achievement of
recent milestones encompassing the identification of many loci for cardiovascular disease …

Precision cardiovascular medicine: state of genetic testing

JR Giudicessi, IJ Kullo, MJ Ackerman - Mayo Clinic Proceedings, 2017 - Elsevier
In the 15 years following the release of the first complete human genome sequences, our
understanding of rare and common genetic variation as determinants of cardiovascular …

The Expansion of Genetic Testing in Cardiovascular Medicine: Preparing the Cardiology Community for the Changing Landscape

N Reza, RL Alford, JW Belmont, N Marston - Current cardiology reports, 2024 - Springer
Abstract Purpose of Review Pathogenic DNA variants underlie many cardiovascular disease
phenotypes. The most well-recognized of these include familial dyslipidemias …

Implementing genome-driven personalized cardiology in clinical practice

A Pasipoularides - Journal of molecular and cellular cardiology, 2018 - Elsevier
Genomics designates the coordinated investigation of a large number of genes in the
context of a biological process or disease. It may be long before we attain comprehensive …

Current genomics in cardiovascular medicine

V Sawhney, S Brouilette, D Abrams… - Current …, 2012 - ingentaconnect.com
Cardiovascular disease (CVD) is a heterogeneous, complex trait that has a major impact on
human morbidity and mortality. Common genetic variation may predispose to common forms …