Reductive stress in inflammation-associated diseases and the pro-oxidant effect of antioxidant agents

I Pérez-Torres, V Guarner-Lans… - International journal of …, 2017 - mdpi.com
Reductive stress (RS) is the counterpart oxidative stress (OS), and can occur in response to
conditions that shift the redox balance of important biological redox couples, such as the …

Antioxidant and prooxidant mechanisms in the regulation of redox (y)-sensitive transcription factors

JJ Haddad - Cellular signalling, 2002 - Elsevier
A progressive rise of oxidative stress due to the altered reduction–oxidation (redox)
homeostasis appears to be one of the hallmarks of the processes that regulate gene …

Oxidative stress: Concept and some practical aspects

H Sies - Antioxidants, 2020 - mdpi.com
Oxidative stress is defined as “an imbalance between oxidants and antioxidants in favor of
the oxidants, leading to a disruption of redox signaling and control and/or molecular …

Redox regulation of the immune response

G Morris, M Gevezova, V Sarafian… - Cellular & Molecular …, 2022 - nature.com
The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Cellular and molecular mechanisms in oxidative stress-related diseases

A Remigante, R Morabito - International Journal of Molecular Sciences, 2022 - mdpi.com
The redox equilibrium is important in preserving the correct functionality of vital cellular
functions. Oxidative stress occurs in both nucleated and non-nucleated cells, and is defined …

Redox activation of Nrf2 & NF-κB: a double end sword?

M Buelna-Chontal, C Zazueta - Cellular signalling, 2013 - Elsevier
Moderate concentrations of reactive oxygen species (ROS) are produced by diverse sources
under physiological conditions. At such low levels, these molecules may act as upstream …

Redox regulation of inflammation: old elements, a new story

Y Lei, K Wang, L Deng, Y Chen… - Medicinal research …, 2015 - Wiley Online Library
Inflammation is an essential immune response characterized by pain, swelling, redness,
heat, and impaired function. A controlled acute inflammatory response is necessary to fight …

Oxidative stress interference with the nuclear factor-κB activation pathways

S Schoonbroodt, J Piette - Biochemical pharmacology, 2000 - Elsevier
While intracellular redox balance is tightly controlled in many cell types, its modification
leads to important cellular changes derived, in part, from a modification of the pattern of …

Antioxidant and oxidative stress: a mutual interplay in age-related diseases

BL Tan, ME Norhaizan, WPP Liew… - Frontiers in …, 2018 - frontiersin.org
Aging is the progressive loss of organ and tissue function over time. Growing older is
positively linked to cognitive and biological degeneration such as physical frailty …

[PDF][PDF] The interplay of oxidative stress and inflammation: mechanistic insights and therapeutic potential of antioxidants

AM Mahmoud, FL Wilkinson, MA Sandhu… - … Medicine and Cellular …, 2021 - researchgate.net
Oxidative stress is caused by the overproduction of Reactive Oxygen Species (ROS) and
diminished cellular antioxidant defenses. Under physiological conditions, ROS are involved …