Objective: This retrospective study aimed to evaluate children observed for suspected
precocious puberty in 5 Italian centers of Pediatric Endocrinology during the first wave of …

Background The timing of puberty in girls is occurring at an increasingly early age. While a
positive family history is recognised as a predisposing factor for early or precocious puberty …

Sexual development is a complex mechanism activated by the hypothalamic-pituitary-
gonadal axis. Over the last one hundred years there has been a decline in the age at …

During the year 2020, the COVID-19 pandemic rapidly became a severe health emergency
worldwide. In order to contrast the spread of the novel SARS-CoV-2, many countries …

A significant increase in precocious puberty, rapidly progressive puberty and precocious
menarche has been reported in Italy since the initial lockdown because of the pandemic …

Abstract Backgrounds During the Coronavirus-19 disease (Covid-19) pandemic it was
observed that the number of girls presenting with early puberty had increased. The aim of …

At the end of 2019, an emerging atypical pneumonia called COVID-19 (coronavirus disease
2019), caused by the novel coronavirus defined as SARS-CoV-2 (Severe Acute Respiratory …

Objective: Early puberty is development of secondary sex characteristics earlier than the
expected normal age range. We subjectively observed an increased frequency of early …

Home quarantine due to the global coronavirus disease 2019 (COVID‐19) pandemic has
had a significant impact on children. Lifestyle changes have led to an increase in precocious …

Background While several studies have been published so far on the effect of COVID-19
pandemic on health care for non-COVID-19 diseases, to date no study evaluated the impact …