Background Hypothalamic-pituitary-adrenal (HPA) axis abnormalities in major depression
(MDD) have been consistently reported in psychiatry and extend to several neurosteroids …

Background In recent years, a relationship between depression and basal
dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) levels has …

Background Major depressive disorder (MDD) has been associated with low
dehydroepiandrosterone-sulphate (DHEAS),–particularly relative to high cortisol–although …

Objective The pathophysiology of major depressive disorder (MDD) is still not well
understood. Conflicting results for surrogate biomarkers in MDD have been reported, which …

Background Dehydroepiandrosterone (DHEA) and its sulfated ester DHEA-sulfate (DHEA-
S),(together DHEA [S]), are the most abundant adrenal steroids in humans and are found in …

Background Alterations in hypothalamic–pituitary–adrenal (HPA)-axis activity, fatty acid
metabolism, and their relation have been associated with (recurrent) major depressive …

Depression is one of the major causes of disability worldwide, but the complete etiology of
depression is not fully understood. Dehydroepiandrosterone (DHEA) and its sulphated form …

Background: Psychosocial stress is a significant public health problem inducing
consequences for quality of life. Results about the use of dehydroepiandrosterone (DHEA) …

Stress is associated with activation of the hypothalamus-adrenal-axis (HPA). Cortisol, a
product of the HPA, is thought to predict depression. However, to date, the majority of studies …

Methods We conducted a narrative review aiming to investigate the role of DHEA in
depression. Study design, search criteria, identification and critical evaluation of results …