Disorders characterized by α-synuclein (α-syn) accumulation, Lewy body formation and
parkinsonism (and in some cases dementia) are collectively known as Lewy body diseases …

Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …

α-Synuclein (α-syn) is an intrinsically disordered protein abundantly distributed in
presynaptic terminals. Aggregation of α-syn into Lewy bodies (LB) is a molecular hallmark of …

Alpha-synuclein (α-syn) is a small protein that, in neurons, localizes predominantly to
presynaptic terminals. Due to elevated conformational plasticity, which can be affected by …

Cytoplasmic deposition of aberrantly misfolded α-synuclein (α-Syn) is a common feature of
synucleinopathies, including Parkinson's disease (PD). However, the precise pathogenic …

A better understanding of the molecular and cellular determinants that influence the
pathology of Parkinson's disease (PD) is essential for developing effective diagnostic …

Abstract Alpha-synuclein (α-syn) is an abundant neuronal protein whose physiological
function, even if still not completely understood, has been consistently related to synaptic …

α-Synuclein (α-syn), a small highly conserved presynaptic protein containing 140 amino
acids, is thought to be the main pathological hallmark in related neurodegenerative …

α-Synuclein (αsyn) is an abundant brain neuronal protein that can misfold and polymerize to
form toxic fibrils coalescing into pathologic inclusions in neurodegenerative diseases …

Over the last two decades, many experimental and clinical studies have provided solid
evidence that alpha-synuclein (α-syn), a small, natively unfolded protein, is closely related to …