α-synuclein (α-syn) is a synaptic protein in which four mutations (A53T, A30P, E46K and
gene triplication) have been found to cause an autosomal dominant form of Parkinson's …

For more than a decade numerous evidence has been reported on the mechanisms of
toxicity of α-synuclein (αS) oligomers and aggregates in α-synucleinopathies. These species …

Intracellular accumulation of α‐synuclein (α‐Syn) as filamentous aggregates is a
pathological feature shared by Parkinson's disease, dementia with Lewy bodies and …

Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …

Aggregation of α-synuclein (α-syn), a process that generates oligomeric intermediates, is a
common pathological feature of several neurodegenerative disorders. Despite the potential …

Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …

α-Synuclein amyloid aggregation is a defining molecular feature of Parkinson's disease,
Lewy body dementia, and multiple system atrophy, but can also be found in other …

Cell-to-cell transmission and subsequent amplification of pathological proteins promote
neurodegenerative disease progression. Most research on this has focused on pathological …

Misfolding and aggregation of alpha‐synuclein (α‐synuclein) with concomitant cytotoxicity is
a hallmark of Lewy body related disorders such as Parkinson's disease, dementia with Lewy …

α-Synuclein (α-syn) is the most abundant protein found in Lewy bodies, a hallmark of
Parkinson's disease (PD), and can aggregate to form toxic oligomers and fibrillar structures …