The pathological aggregation of the presynaptic protein α-synuclein (α-syn) and propagation
through synaptically coupled neuroanatomical tracts is increasingly thought to underlie the …

α-Synuclein (αS) is a small, unstructured, presynaptic protein expressed in the brain. Its
aggregated form is a major component of Lewy bodies, the large proteinaceous deposits in …

Parkinson's disease is the second most common neurodegenerative disorder. Although the
pathogenesis of Parkinson's disease is not entirely clear, the aberrant aggregation of α …

Summary α-Synuclein (α-syn) has been shown to form various conformational fibrils
associated with different synucleinopathies. But whether the conformation of α-syn fibrils …

Alpha‐synuclein (α‐syn) is a small soluble protein expressed primarily at presynaptic
terminals in the central nervous system. Interest in α‐syn has increased dramatically after …

α-Synuclein (α-syn) is a presynaptic protein that regulates the release of neurotransmitters
from synaptic vesicles in the brain. α-Syn aggregates, including Lewy bodies, are features of …

Alpha-synuclein (α-syn), a synaptic protein richly expressed in the central nervous system,
has been implicated in several neurodegenerative diseases, such as Alzheimer's disease …

Biochemcal and genetic evidence point towards α-synuclein aggregation as having a pivotal
role in the onset and progression of several neurodegenerative disorders, including …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar neuronal
inclusions composed of aggregated α-synuclein (α-syn). These inclusions are associated …

The accumulation of misfolded alpha-synuclein (aSyn) throughout the brain, as Lewy
pathology, is a phenomenon central to Parkinson's disease (PD) pathogenesis. The …