[HTML][HTML] A tetravalent bispecific antibody outperforms the combination of its parental antibodies and neutralizes diverse SARS-CoV-2 variants

A Chiyyeadu, G Asgedom, M Bruhn, C Rocha… - Clinical …, 2024 - Elsevier
The devastating impact of COVID-19 on global health shows the need to increase our
pandemic preparedness. Recombinant therapeutic antibodies were successfully used to …

[HTML][HTML] Synthetic repertoires derived from convalescent COVID-19 patients enable discovery of SARS-CoV-2 neutralizing antibodies and a novel quaternary binding …

J Goike, CL Hsieh, A Horton, EC Gardner, F Bartzoka… - Biorxiv, 2021 - ncbi.nlm.nih.gov
The ongoing evolution of SARS-CoV-2 into more easily transmissible and infectious variants
has sparked concern over the continued effectiveness of existing therapeutic antibodies and …

A synthetic bispecific antibody capable of neutralizing SARS-CoV-2 Delta and Omicron

TZ Yuan, C Lucas, VS Monteiro, A Iwasaki, ML Yang… - bioRxiv, 2022 - biorxiv.org
Bispecific antibodies have emerged as a promising strategy for curtailing severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) immune escape. This brief report …

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

AK Wheatley, P Pymm, R Esterbauer, MH Dietrich… - Cell Reports, 2021 - cell.com
Potent neutralizing monoclonal antibodies are one of the few agents currently available to
treat COVID-19. SARS-CoV-2 variants of concern (VOCs) that carry multiple mutations in the …

Impact of the N501Y substitution of SARS-CoV-2 Spike on neutralizing monoclonal antibodies targeting diverse epitopes

L Cheng, S Song, B Zhou, X Ge, J Yu, M Zhang, B Ju… - Virology journal, 2021 - Springer
The emergence and rapid spread of the B. 1.1. 7 lineage (VOC-202012/01) SARS-CoV-2
variant has aroused global concern. The N501Y substitution is the only mutation in the …

Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2

Q Zhang, B Ju, J Ge, JFW Chan, L Cheng… - Nature …, 2021 - nature.com
Neutralizing antibodies (nAbs) to SARS-CoV-2 hold powerful potentials for clinical
interventions against COVID-19 disease. However, their common genetic and biologic …

IMM-BCP-01, a patient-derived anti–SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA. 1 and BA. 2

PA Nikitin, JM DiMuzio, JP Dowling, NB Patel… - Science …, 2022 - science.org
Monoclonal antibodies are an efficacious therapy against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). However, rapid viral mutagenesis led to escape …

An engineered bispecific human monoclonal antibody against SARS-CoV-2

Z Li, S Li, G Zhang, W Peng, Z Chang, X Zhang… - Nature …, 2022 - nature.com
The global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
requires effective therapies against coronavirus disease 2019 (COVID-19), and neutralizing …

A novel bispecific antibody dual-targeting approach for enhanced neutralization against fast-evolving SARS-CoV-2 variants

JW Kim, HJ Kim, K Heo, Y Lee, HJ Jang… - Frontiers in …, 2023 - frontiersin.org
Introduction The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants has caused unprecedented health and socioeconomic crises, necessitating …

Potent neutralization of SARS-CoV-2 variants of concern by an antibody with an uncommon genetic signature and structural mode of spike recognition

KJ Kramer, NV Johnson, AR Shiakolas, N Suryadevara… - Cell Reports, 2021 - cell.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages
that are more transmissible and resistant to currently approved antibody therapies poses a …