The phenotypic expression of sickle cell anaemia varies greatly among patients and
longitudinally in the same patient. It influences all aspects of the life of affected individuals …

The phenotypic expression of sickle cell disease (SCD) varies greatly among patients and
longitudinally in the same patient. The phenotype influences all aspects of the life of affected …

Background: Sickle cell disease causes significant morbidity and mortality and affects the
economic and healthcare status of many countries. Yet historically, the disease has not had …

Sickle cell disease (SCD) is a global public health disorder that affects millions of people
across the globe. It is a monogenic disorder caused by an A-to-T point mutation in the β …

Sickle cell disease (SCD) is an inherited disorder of hemoglobin structure that has no
established cure in adult patients. Cure has been achieved in selected children with sickle …

The landscape of sickle cell disease (SCD) treatment continues to evolve rapidly, with new
disease-modifying therapies in development and potentially curative options on the horizon …

The discovery of the molecular basis of sickle cell disease was an important landmark in
molecular medicine. The modern tools of molecular and cellular biology have refined our …

Sickle cell disease (SCD) is a heterogeneous disorder, with clinical manifestations including
chronic haemolysis, an increased susceptibility to infections and vaso-occlusive …

There is a great diversity in the clinical manifestations of sickle cell anemia. Some patients
have severe repetitive infarctive episodes culminating in organ failure. Others have minor …

Sickle cell anemia occurs in individuals who are homozygous for a single nucleotide
substitution in codon 6 of the beta-globin gene. This single mutation leads to the formation of …