Triple combination therapy with 2 antivirals and monoclonal antibodies for persistent or relapsed severe acute respiratory syndrome coronavirus 2 infection in …

M Mikulska, C Sepulcri, C Dentone… - Clinical Infectious …, 2023 - academic.oup.com
Background Severely immunocompromised patients are at risk for prolonged or relapsed
Coronavirus Disease 2019 (COVID-19), leading to increased morbidity and mortality. We …

Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19

F Baldi, C Dentone, M Mikulska, D Fenoglio… - Frontiers in …, 2023 - frontiersin.org
COVID-19 in immunocompromised patients is difficult to treat. SARS-CoV-2 interaction with
the host immune system and the role of therapy still remains only partly understood. There …

Reinfection of severe acute respiratory syndrome coronavirus 2 in an immunocompromised patient: a case report

M Mulder, DSJM van der Vegt… - Clinical Infectious …, 2021 - academic.oup.com
Potential conflicts of interest. P. LW reports personal fees from Gilead, Pfizer, F2G, and MSD
and meeting sponsorship from Dynamiker, Bruker, and Launch outside the submitted work …

Rapid selection of sotrovimab escape variants in severe acute respiratory syndrome coronavirus 2 Omicron-infected immunocompromised patients

S Gliga, N Lübke, A Killer, H Gruell… - Clinical Infectious …, 2023 - academic.oup.com
Background Monoclonal antibodies (mAbs) that target severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) are predominantly less effective against Omicron variants …

Outcomes of targeted treatment in immunocompromised patients with asymptomatic or mild COVID-19: a retrospective study

M Lahouati, C Cazanave, A Labadie, P Gohier… - Scientific Reports, 2023 - nature.com
The aim of this study was to describe the outcomes of targeted COVID-19 treatments in
immunocompromised patients with asymptomatic or mild COVID-19 during the period of …

Persistent SARS-CoV-2 infection in patients with secondary antibody deficiency: successful clearance following combination casirivimab and imdevimab (REGN …

Y Taha, H Wardle, AB Evans, ER Hunter, H Marr… - Annals of clinical …, 2021 - Springer
Background There is growing evidence that antibody responses play a role in the resolution
of SARS-CoV-2 infection. Patients with primary or secondary antibody deficiency are at …

[HTML][HTML] Combination regimen of nirmatrelvir/ritonavir and molnupiravir for the treatment of persistent SARS-CoV-2 infection: A case report and a scoping review of the …

D Marangoni, RM Antonello, M Coppi… - International Journal of …, 2023 - Elsevier
Immunocompromised patients still experience unpredictable courses of COVID-19, despite
that effective vaccines and drugs against SARS-CoV-2 are now available. Antiviral …

Successful combination treatment for persistent severe acute respiratory syndrome coronavirus 2 infection

O Blennow, J Vesterbacka, T Tovatt… - Clinical Infectious …, 2023 - academic.oup.com
Another recent publication reported success with a combination of monoclonal antibodies, 7
days of remdesivir, and 5 days of nirmatrelvir/ritonavir [2]. Influenced by the report from …

Novel treatment combining antiviral and neutralizing antibody-based therapies with monitoring of spike-specific antibody and viral load for immunocompromised …

D Wada, Y Nakamori, S Maruyama, H Shimazu… - … hematology & oncology, 2022 - Springer
Because prolonged viral replication of SARS-CoV-2 is increasingly being recognized
among immunocompromised patients, subacute or chronic COVID-19 pneumonia can …

[HTML][HTML] Persistent SARS-CoV-2 infection in immunocompromised patients facilitates rapid viral evolution: Retrospective cohort study and literature review

D Hettle, S Hutchings, P Muir, E Moran… - Clinical Infection in …, 2022 - Elsevier
Background Most patients with SARS-CoV-2 are non-infectious within 2 weeks, though viral
RNA may remain detectable for weeks. However there are reports of persistent SARS-CoV-2 …