Diabetes is a metabolic disorder with multiple complications, including cardiomyopathy,
retinopathy, nephropathy and neuropathy. Diabetic complications are the major cause of …

Apelin is a newly discovered peptide hormone that has recently been linked to insulin
resistance and obesity. Data collected from both the clinical and basic research settings …

Type 2 diabetes mellitus is a common type of diabetes and considered as multifactorial
disease. Apelin is an adipokine which secreted from white adipose tissue and involved in …

Insulin resistance is a main feature of obesity and type 2 diabetes mellitus (T2DM). Several
mechanisms linking obesity to insulin resistance have been proposed. Adipose tissue …

Type 2 diabetes mellitus (T2DM) is an epidemic with an ever-increasing global prevalence.
Current treatment strategies, although plentiful and somewhat effective, often fail to achieve …

Apelin, a peptide with several active isoforms ranging from 36 to 12 amino acids and its
receptor APJ, a G-protein-coupled receptor, are widely distributed. However, apelin has …

Apelin is a peptide known as the ligand of the G-protein-coupled receptor APJ. Several
active apelin forms exist such as apelin-36, apelin-17, apelin-13, and the pyroglutamated …

This paper focuses on the contribution of apelin in obesity associated regulations/
dysregulations. The conclusions are summarized as follows:(i) apelin is produced by fat …

The recently discovered peptide apelin is known to be involved in the maintenance of insulin
sensitivity. However, questions persist regarding its precise role in the chronic setting …

A wide range of adipokines identified over the past years has allowed considering the white
adipose tissue as a secretory organ closely integrated into overall physiological and …