Genetics of childhood steroid sensitive nephrotic syndrome: an update

BM Lane, R Cason, CI Esezobor… - Frontiers in …, 2019 - frontiersin.org
Advances in genome science in the last 20 years have led to the discovery of over 50 single
gene causes and genetic risk loci for steroid resistant nephrotic syndrome (SRNS). Despite …

Treatment of Steroid and Cyclosporine‐Resistant Idiopathic Nephrotic Syndrome in Children

AA Nikibakhsh, H Mahmoodzadeh… - International Journal …, 2011 - Wiley Online Library
Steroid‐resistant nephrotic syndrome (SRNS) in children carries a significant risk of
progression to end‐stage renal failure (ESRF). We report a two‐step protocol adapted in …

Exploring the clinical and genetic spectrum of steroid resistant nephrotic syndrome: the PodoNet registry

A Trautmann, BS Lipska-Ziętkiewicz… - Frontiers in …, 2018 - frontiersin.org
Background: Steroid resistant nephrotic syndrome (SRNS) is a rare condition, accounting for
10–15% of all children with idiopathic nephrotic syndrome. SRNS can be caused by genetic …

Therapies for steroid-resistant nephrotic syndrome

EM Hodson, JC Craig - Pediatric nephrology, 2008 - Springer
Between 10 and 20% of children with primary nephrotic syndrome are steroid-resistant
(SRNS). From earlier studies in children with SRNS, we know that cyclosporin (with or …

Current understanding of nephrotic syndrome in children

TK Mattoo, S Sanjad - Pediatric Clinics, 2022 - pediatric.theclinics.com
Nephrotic syndrome (NS) in children is characterized by the presence of significant
proteinuria, hypoalbuminemia, and edema. About 90% of the cases between 1 and 10 years …

Cyclophosphamide in steroid-dependent nephrotic syndrome

S Azib, MA Macher, T Kwon, A Dechartres, C Alberti… - Pediatric …, 2011 - Springer
In order to determine the long-term effects of cyclophosphamide (CPO) and to identify
parameters associated with sustained remission, we retrospectively studied the data from 90 …

An updated view of the pathogenesis of steroid-sensitive nephrotic syndrome

T Horinouchi, K Nozu, K Iijima - Pediatric Nephrology, 2022 - Springer
Idiopathic nephrotic syndrome is the most common childhood glomerular disease. Most
forms of this syndrome respond to corticosteroids at standard doses and are, therefore …

Long-term outcomes in children with steroid-resistant nephrotic syndrome treated with calcineurin inhibitors

NT Beins, KM Dell - Frontiers in Pediatrics, 2015 - frontiersin.org
Background Steroid-resistant nephrotic syndrome (SRNS) is an important cause of chronic
kidney disease (CKD) in children that often progresses to end-stage renal disease (ESRD) …

Early age at debut is a predictor of steroid-dependent and frequent relapsing nephrotic syndrome

RF Andersen, N Thrane, K Noergaard, L Rytter… - Pediatric …, 2010 - Springer
The purpose of this study was to identify characteristics of patients with steroid-sensitive
nephrotic syndrome (SSNS) that point to a high risk of frequent relapsing (FR) or steroid …

Treatment of steroid resistant nephrotic syndrome in children

JA Kari, M Halawani - Saudi journal of kidney Diseases and …, 2010 - journals.lww.com
Achieving remission in children with Steroid-Resistant Nephrotic Syndrome (SRNS) could
be difficult. Many immunosuppressive drugs are used with variable success rates. We have …