Anti-psma antibody-drug conjugates and immunotoxins
P Wolf - Antibody-Drug Conjugates and Immunotoxins: From …, 2012 - Springer
The prostate-specific membrane antigen (PSMA) represents a valuable antigen for the
generation of antibody–drug conjugates (ADCs), since it is present on the cell surface at all …
generation of antibody–drug conjugates (ADCs), since it is present on the cell surface at all …
Clinical and preclinical advances in PSMA-Directed Antibody-Drug conjugates (ADCs): Current status and hope for the future
Y Mirzaei, AH Mer, B fattah Maran, L Omidvar… - Bioorganic …, 2024 - Elsevier
Prostate-specific membrane antigen (PSMA) is a type II membrane glycoprotein
overexpressed in a variety of tumors, especially in nearly all prostate cancers, which makes …
overexpressed in a variety of tumors, especially in nearly all prostate cancers, which makes …
[PDF][PDF] Antibody-drug conjugates targeting prostate-specific membrane antigen
WC Olson, RJ Israel - Front Biosci (Landmark Ed), 2014 - article.imrpress.com
Cell-surface markers of prostate cancer 3. PSMA as a target for cancer therapy 4. Antibody-
drug conjugate chemistries 5. Preclinical findings 5.1. PSMA ADC 5.2. MLN2704 5.3 …
drug conjugate chemistries 5. Preclinical findings 5.1. PSMA ADC 5.2. MLN2704 5.3 …
Efficacy studies of an antibody‐drug conjugate PSMA‐ADC in patient‐derived prostate cancer xenografts
VA DiPippo, WC Olson, HM Nguyen, LG Brown… - The …, 2015 - Wiley Online Library
BACKGROUND It is timely and important to develop new treatment modalities for advanced
prostate cancer, because even the newly FDA approved treatments, despite providing …
prostate cancer, because even the newly FDA approved treatments, despite providing …
An anti‐PSMA bivalent immunotoxin exhibits specificity and efficacy for prostate cancer imaging and therapy
F Zhang, L Shan, Y Liu, D Neville… - Advanced …, 2013 - Wiley Online Library
Prostate specific membrane antigen (PSMA) is overexpressed on prostate tumor cells and
the neovascular endothelia various solid tumors. A bivalent immunotoxin generated by …
the neovascular endothelia various solid tumors. A bivalent immunotoxin generated by …
Anti‐tumor effects and lack of side effects in mice of an immunotoxin directed against human and mouse prostate‐specific membrane antigen
X Huang, M Bennett, PE Thorpe - The Prostate, 2004 - Wiley Online Library
Background Prostate‐specific membrane antigen (PSMA) is a transmembrane protein that is
largely restricted to prostatic epithelial cells in humans and is strongly upregulated on …
largely restricted to prostatic epithelial cells in humans and is strongly upregulated on …
In vitro evaluation of humanized/de-immunized anti-PSMA immunotoxins for the treatment of prostate cancer
M Michalska, S Schultze-Seemann… - Anticancer …, 2018 - ar.iiarjournals.org
Background: We generated humanized/de-immunized immunotoxins targeting the prostate-
specific membrane antigen (PSMA) and tested their cytotoxic activity against prostate cancer …
specific membrane antigen (PSMA) and tested their cytotoxic activity against prostate cancer …
Phase 1 study of PSMA ADC, an antibody‐drug conjugate targeting prostate‐specific membrane antigen, in chemotherapy‐refractory prostate cancer
DP Petrylak, P Kantoff, NJ Vogelzang, A Mega… - The …, 2019 - Wiley Online Library
Background Prostate‐specific membrane antigen (PSMA) is a well‐characterized target that
is overexpressed selectively on prostate cancer cells. PSMA antibody‐drug conjugate (ADC) …
is overexpressed selectively on prostate cancer cells. PSMA antibody‐drug conjugate (ADC) …
PSMA ADC improved survival and reduced measurable tumor burden in a subcutaneous mouse xenograft model of human prostate cancer
D Ma, H Zhang, P Maddon, T Parsons, W Olson - Cancer Research, 2008 - AACR
Abstract 4058 Introduction: Prostate-specific membrane antigen (PSMA) is an attractive
target for immunotherapy of prostate cancer due to its abundant expression on the surface of …
target for immunotherapy of prostate cancer due to its abundant expression on the surface of …
Current Status of Radiolabeled Monoclonal Antibodies Targeting PSMA for Imaging and Therapy
M Abusalem, L Martiniova, S Soebianto, L DePalatis… - Cancers, 2023 - mdpi.com
Simple Summary The prostate-specific membrane antigen (PSMA) protein present in most
prostate cancer cells has emerged as a promising target for the imaging and treatment of …
prostate cancer cells has emerged as a promising target for the imaging and treatment of …